FB2024_03 , released June 25, 2024
Allele: Dmel\Dcr-1UAS.cDa
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General Information
Symbol
Dmel\Dcr-1UAS.cDa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Dietzl
FlyBase ID
FBal0216507
Feature type
allele
Associated gene
Dmel\Dcr-1
Associated Insertion(s)
Carried in Construct
P{UAS-Dcr-1.D}
Also Known As
UAS-Dicer-1, UAS-dcr1
Key Links
Transgenic product class
wild_type
(Dietzl et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Dietzl et al., 2007)
Mutagen
in vitro construct
(Dietzl et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Dcr-1.D}
Cytology
Description

UAS regulatory sequences drive expression of Dcr-1.

(Dietzl et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Dcr-1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by LrrkI1915T.UAS
      (Gehrke et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Co-expression of Dcr-1Scer\UAS.cDa restores cell and tissue size in wings expressing Scer\GAL4en-e16E>Dcr-1GD11429.

      (Herranz et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In flies expressing LrrkI1915T.Scer\UAS driven by Scer\GAL4ple.PF, Dcr-1Scer\UAS.cDa-overexpression suppresses the neuronal toxicity of LrrkI1915T.Scer\UAS.

      (Gehrke et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Dcr-1UAS.cDa/Scer\GAL4GH146 rescues Dcr-1LL06357

      (Berdnik et al., 2008)
      Comments

      Expression of Dcr-1Scer\UAS.cDa under the control of Scer\GAL4GH146 rescues the projection neuron defects seen in Dcr-1LL06357 projection neuron neuroblast clones (MARCM clones labelled using Scer\GAL4GH146).

      Expression of Dcr-1Scer\UAS.cDa under the control of Scer\GAL4GH146 rescues the projection neuron defects (both the dendritic and axon defects) seen in single cell Dcr-1LL06357 DL1 projection neuron clones.

      (Berdnik et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dcr-1Scer\UAS.cDa
      Dcr-1UAS.cDa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Dietzl
      Secondary FlyBase IDs
        References (9)