FlyBase Allele Report: Dmel\egg[10.1a]

General Information

Symbol

Dmel\egg^10.1a

Species

D. melanogaster

Name

FlyBase ID

FBal0219059

Feature type

allele

Associated gene

Dmel\egg

Associated Insertion(s)

TI{TI}egg^10.1a

Carried in Construct

Also Known As

DmSetdb1^10.1a, dSetdb1^10.1a

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Seum et al., 2007)

Mutagen

recombination

(Seum et al., 2007)

gene targeting by homologous recombination

(Seum et al., 2007)

Progenitor genotype

Associated Insertion(s)

TI{TI}egg^10.1a

Cytology

Polytene chromosomes normal

(Seum et al., 2007)

Description

Deletion of the genomic fragment encoding amino acids 421 to 1261 of egg. The w[+] marker flanked by loxP sites that was inserted as part of the original recombination event has been excised.

(Seum et al., 2007)

Allele components

Component

Use(s)

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:24,775,600..24,778,424 [-]

Comment:

A deletion of a genomic fragment encoding amino acids 421 to 1261 of egg.

(Seum et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage (with Df(2R)Dll-MP)

(Clough et al., 2014)

abnormal locomotor behavior | adult stage (with Df(2R)ED4065)

(Clough et al., 2014)

lethal | male (with Df(2R)ED4065)

(Clough et al., 2014)

lethal - all die before end of pupal stage | recessive

(Seum et al., 2007)

partially lethal - majority die (with Df(2R)Dll-MP)

(Clough et al., 2014)

partially lethal - majority die (with Df(2R)ED4065)

(Clough et al., 2014)

short lived | male (with Df(2R)Dll-MP)

(Clough et al., 2014)

some die during pupal stage | recessive

(Seum et al., 2007)

suppressor of variegation

(Cryderman et al., 2011)

suppressor of variegation | recessive

(Seum et al., 2007)

visible | adult stage (with Df(2R)Dll-MP)

(Clough et al., 2014)

visible | adult stage (with Df(2R)ED4065)

(Clough et al., 2014)

Phenotype Manifest In

wing (with Df(2R)Dll-MP)

(Clough et al., 2014)

wing (with Df(2R)ED4065)

(Clough et al., 2014)

Detailed Description

Statement

Reference

egg^10.1a/Df(2R)Dll-MP transheterozygotes are semi-lethal, display a low male:female ratio, and the few males die within 2-3 days; egg^10.1a/Df(2R)ED4065 transheterozygotes are near lethal and no adult males eclose. egg^10.1a/Df(2R)Dll-MP and egg^10.1a/Df(2R)ED4065 transheterozygous adults exhibit shaky, uncoordinated movements and held-out wings that are incompletely expanded, as compared to controls; the locomotor and wing phenotypes of egg^10.1a/Df(2R)Dll-MP transheterozygotes are more pronounced in males than in females.

(Clough et al., 2014)

egg^10.1a suppresses the position effect variegation of the w gene that is seen in the P{hsp26-pt-T}Dyrk3^118E-15 insertion.

(Cryderman et al., 2011)

Homozygous egg^10.1a mutants die at late pupal stage with no escapers. The same phenotype is observed in individuals transheterozygous for egg^10.1a and the chromosomal deficiency Df(2R)ED4065.

egg^10.1a is a recessive suppressor of variegation of chromosome 4.

(Seum et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

egg¹⁴⁷³/egg^10.1a is a suppressor of phenotype of Su(var)205^hs.lacI(DBD)

(Hines et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

egg^10.1a is partially rescued by Scer\GAL4^da.G32/egg^{421-1261.UASp}

(Seum et al., 2007)

egg^10.1a is partially rescued by egg^{421-1261.UASp.Tag:HA}/Scer\GAL4^da.G32

(Seum et al., 2007)

Comments

The Scer\GAL4^da.G32-driven egg^{421-1261.Scer\UAS.P\T.T:Ivir\HA}-rescued and Scer\GAL4^da.G32-driven egg^{421-1261.Scer\UAS.P\T}-rescued females are sterile, while the males are fertile.

(Seum et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

DmSetdb1^10.1a

(Seum et al., 2007, Seum et al., 2007)

dSetdb1^10.1a

(Clough et al., 2014, Cryderman et al., 2011)

dmSetDB1^10.1a

(Hines et al., 2009)

egg^10.1a

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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