FB2024_03 , released June 25, 2024
Allele: Dmel\Su(var)205hs.lacI(DBD)
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General Information
Symbol
Dmel\Su(var)205hs.lacI(DBD)
Species
D. melanogaster
Name
FlyBase ID
FBal0147400
Feature type
allele
Associated gene
Dmel\Su(var)205
Associated Insertion(s)
Carried in Construct
P{hs-HP1.lacI.BD}
Also Known As
lacI-HP1
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Li et al., 2003)
Progenitor genotype
Carried in construct
P{hs-HP1.lacI.BD}
Cytology
Description

An Hsp70 promoter drives expression of Su(var)205 that is tagged at the N-terminal end with lacI(DBD).

(Li et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Su(var)205
Tagged with
lacI(DBD)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Su(var)205hs.lacI(DBD) has phenotype, suppressible by egg1473/egg10.1a

      (Hines et al., 2009)
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of one copy of Su(var)205hs.T:Ecol\lacI-DNA-BD partially suppresses the midgut hyperplasia seen when LamGD1478 is expressed under the control of Scer\GAL4Cg.PA.

      (Chen et al., 2014)

      w256x.Ecol\lacO, Su(var)205hs.T:Ecol\lacI animals usually exhibit silencing of the w gene, unless the P{Ecol\lacO.256x.w} insertion is very close to a gene. This suppression is not affected by the addition of Su(var)3-96.

      Tethered Su(var)205 (in Su(var)205hs.T:Ecol\lacI, w256x.Ecol\lacO) causes ectopic intra or inter-chromosomal associations, in about half of the nuclei examined in affected insertion lines. The addition of Su(var)3-9hs.T:Avic\GFP-EGFP increases that proportion to nearly 100%.

      (Li et al., 2003)

      w256x.Ecol\lacO, Su(var)205hs.T:Ecol\lacI animals usually exhibit silencing of the w gene. unless the P{Ecol\lacO.256x.w} insertion is very close to a gene. This suppression is not affected by the addition of Su(var)3-96. Tethered Su(var)205 (in Su(var)205hs.T:Ecol\lacI, w256x.Ecol\lacO) causes ectopic intra or inter-chromosomal associations, in about half of the nuclei examined in affected insertion lines. The addition of Su(var)3-9hs.T:Avic\GFP-EGFP increases that proportion to nearly 100%.

      (Li et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Su(var)205hs.T:Ecol\lacI-DNA-BD
      Su(var)205hs.T:Ecol\lacI
      Su(var)205hs.lacI(DBD)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)