FlyBase Allele Report: Dmel\erm[JF02342]

General Information

Symbol

Dmel\erm^JF02342

Species

D. melanogaster

Name

FlyBase ID

FBal0220710

Feature type

allele

Associated gene

Dmel\erm

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02342}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

(Perkins et al., 2009.3.31)

Progenitor genotype

Carried in construct

P{TRiP.JF02342}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.3.31)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02342

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^pnt-14-94

(Chen et al., 2021)

abnormal neuroanatomy | larval stage, with Scer\GAL4^wor.PU, Scer\GAL80^ase.PN

(Zhang et al., 2019)

increased cell number | larval stage, with Scer\GAL4^pnt-14-94

(Chen et al., 2021)

increased cell number | larval stage, with Scer\GAL4^wor.PU, Scer\GAL80^ase.PN

(Zhang et al., 2019)

Phenotype Manifest In

embryonic/larval brain | larval stage, with Scer\GAL4^pnt-14-94

(Chen et al., 2021)

type II neuroblast | increased number | larval stage, with Scer\GAL4^pnt-14-94

(Chen et al., 2021)

type II neuroblast | larval stage, with Scer\GAL4^wor.PU, Scer\GAL80^ase.PN

(Zhang et al., 2019)

Detailed Description

Statement

Reference

The expression of erm^JF02342 under the control of Scer\GAL4^pnt-14-94 or Scer\GAL4^GMR9D11 leads to an increase in the number of type II neuroblasts in the larval brain.

(Chen et al., 2021)

The expression of IntS2^KK100750 under the combined control of Scer\GAL4^wor.PU, Scer\GAL80^ase.PN and Dicer-2 (for an efficient RNAi) does not affect the number of type II neuroblasts within type II lineages in the larval brain, despite causing an ectopic number of type II neuroblast lineages per hemisphere.

(Zhang et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^pnt-14-94, erm^JF02342 has increased cell number | larval stage phenotype, enhanceable by Six4^HM05254/Scer\GAL4^pnt-14-94

(Chen et al., 2021)

Scer\GAL4^pnt-14-94, erm^JF02342 has abnormal neuroanatomy | larval stage phenotype, enhanceable by Six4^HM05254/Scer\GAL4^pnt-14-94