FB2024_03 , released June 25, 2024
Allele: Dmel\bunGE12327
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General Information
Symbol
Dmel\bunGE12327
Species
D. melanogaster
Name
FlyBase ID
FBal0221065
Feature type
allele
Associated gene
Dmel\bun
Associated Insertion(s)
P{EP}bunGE12327
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Gluderer et al., 2008)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EP}bunGE12327
    Cytology
    Description

    Insertion in the 5'UTR of the bun A isoform and in an intron of the bun F isoform.

    (Gluderer et al., 2008)
    Allele components
    Component
    Use(s)
    Inserted element
    P{EP}
    Regulatory region(s)
    UAS
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygotes eclose with a delay of approximately 36 ours, and 40-70% of the expected homozygotes are recovered (with a slight bias towards males). Homozygous females show a 20% reduction in dry weight.

        bunA-149B/bunGE12327 males and females show a reduction in body weight compared to controls.

        Homozygous and bunA-149B/bunGE12327 females show a reduction in ommatidia number and size compared to controls.

        bunA-Q578X/bunGE12327 flies show ommatidial differentiation defects, especially around the equator, including under-rotated ommatidia, ommatidial fusions and cell fate transformations (with a low frequency, the R4 photoreceptor cell adopts the fate of the R3 cells and a few R7 cells transform to R1/R6 cells.

        (Gluderer et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        bunGE12327, Scer\GAL4ap-md544 is an enhancer of visible phenotype of S6kUAS.cMa, Scer\GAL4ap-md544

        (Gluderer et al., 2008)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        bunGE12327, Scer\GAL4ap-md544 is an enhancer of wing phenotype of S6kUAS.cMa, Scer\GAL4ap-md544

        (Gluderer et al., 2008)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Co-expression of one of bunGE12327 enhances the bent down wing phenotype caused by expression of S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544.

        (Gluderer et al., 2008)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        bunGE12327
        Name Synonyms
        Secondary FlyBase IDs
          References (1)