FlyBase Allele Report: Dmel\ci[KK100760]

General Information

Symbol

Dmel\ci^KK100760

Species

D. melanogaster

Name

FlyBase ID

FBal0230907

Feature type

allele

Associated gene

Dmel\ci

Associated Insertion(s)

Carried in Construct

P{KK100760}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100760}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100760

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell cycle | adult stage, with Scer\GAL4^C587

(Liu et al., 2015)

abnormal neuroanatomy, with Scer\GAL4²²¹

(Iyer et al., 2013)

abnormal neuroanatomy, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

increased cell number, with Scer\GAL4^C587

(Liu et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of ci^KK100760 under the control of Scer\GAL4^C587 results in the presence of supernumerary spectrosome-containing cells in germaria; results in cystoblasts undergoing complete cytokinesis to produce two spectrosome-containing cells instead of forming a two-cell cyst; and leads to closure of the ring canals and breakdown of the fusomes observed in differentiating cysts.

(Liu et al., 2015)

Expressing ci^KK100760 under the control of Scer\GAL4^ey.PH does not cause any overt eye overgrowth.

(Da Ros et al., 2013)

Expression of ci^KK100760 in C-IV neurons under the control of Scer\GAL4^ppk.1.9 results in a reduction in total dendritic length in ddaC, v'ada and vdaB neurons. The total number of dendritic branches is also reduced in ddaC and v'ada neurons.

Expression of ci^KK100760 in C-I neurons under the control of Scer\GAL4²²¹ results in ddaD neurons that have an increased number of dendritic branches compared to controls.

(Iyer et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ci^KK100760, Scer\GAL4^ey.PH is an enhancer of visible | adult stage phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH

(Da Ros et al., 2013)

NOT Enhancer of

Statement

Reference

Scer\GAL4^hh-Gal4/ci^KK100760 is a non-enhancer of increased size | larval stage phenotype of Scer\GAL4^hh-Gal4, hh^UAS.cIa

(Gore et al., 2021)

NOT Suppressor of

Statement

Reference

Scer\GAL4^hh-Gal4/ci^KK100760 is a non-suppressor of increased size | larval stage phenotype of Scer\GAL4^hh-Gal4, hh^UAS.cIa

(Gore et al., 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

ci^KK100760, Scer\GAL4^ey.PH is an enhancer of eye phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH

(Da Ros et al., 2013)

NOT Enhancer of

Statement

Reference

Scer\GAL4^hh-Gal4/ci^KK100760 is a non-enhancer of wing disc anterior compartment | larval stage phenotype of Scer\GAL4^hh-Gal4, hh^UAS.cIa

(Gore et al., 2021)

NOT Suppressor of

Statement

Reference

Scer\GAL4^hh-Gal4/ci^KK100760 is a non-suppressor of wing disc anterior compartment | larval stage phenotype of Scer\GAL4^hh-Gal4, hh^UAS.cIa

(Gore et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

ci^KK100760 enhances the eye overgrowth phenotype seen when Dl^Scer\UAS.cDa is expressed under the control of Scer\GAL4^ey.PH, resulting in flies with secondary eye growths within the thorax and abdomen. The phenotype is seen with 10% penetrance.

(Da Ros et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105620

P{KK100760}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ci^KK100760

ci^v105620

(Liu et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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