FlyBase Allele Report: Dmel\cn[KK101938]

General Information

Symbol

Dmel\cn^KK101938

Species

D. melanogaster

Name

FlyBase ID

FBal0231571

Feature type

allele

Associated gene

Dmel\cn

Associated Insertion(s)

Carried in Construct

P{KK101938}

Also Known As

cn RNAi, cn-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct - RNAi

(Keleman et al., 2009.8.5)

in vitro construct - regulatory fusion

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101938}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101938

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Campesan et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^Act5C.PI

(Maddison et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

cn^KK101938, Scer\GAL4^{repo.Switch.2301} is a non-enhancer of short lived | RU486 conditional phenotype of Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Suppressor of

Statement

Reference

cn^KK101938, Scer\GAL4^elav-C155 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Campesan et al., 2011)

NOT Suppressor of

Statement

Reference

cn^KK101938, Scer\GAL4^{repo.Switch.2301} is a non-suppressor of short lived | RU486 conditional phenotype of Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Phenotype Manifest In

Suppressor of

Statement

Reference

cn^KK101938, Scer\GAL4^elav-C155 is a suppressor of rhabdomere phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Campesan et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of cn^KK101938 partially suppresses the rhabdomere degeneration seen in one day old flies when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155. Some rescue is seen at seven days post-eclosion. The increase in 3-hydroxykynurenine (3-HK)/kynurenic acid (KYNA) ratio is also significantly suppressed.

(Campesan et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105854

P{KK101938}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cn^KK101938

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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