FlyBase Allele Report: Dmel\ND-75[KK108222]

General Information

Symbol

Dmel\ND-75^KK108222

Species

D. melanogaster

Name

FlyBase ID

FBal0235428

Feature type

allele

Associated gene

Dmel\ND-75

Associated Insertion(s)

Carried in Construct

P{KK108222}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108222}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108222

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of nuclear type mitochondrial complex I deficiency 5

CEC

(Granat et al., 2024)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by Wwox^KK108459

(Choo et al., 2015)

modeled by Wwox^GD12175

(Choo et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^ey.PU

(Choo et al., 2015)

increased cell number | third instar larval stage, with Scer\GAL4^Antp-10

(Sinenko et al., 2011)

increased occurrence of cell division | larval stage, with Scer\GAL4^ey.PU

(Choo et al., 2015)

neoplasia | larval stage, with Scer\GAL4^ey.PU

(Choo et al., 2015)

Phenotype Manifest In

eye disc, with Scer\GAL4^ey.PU

(Choo et al., 2015)

lamellocyte | third instar larval stage, with Scer\GAL4^Antp-10

(Sinenko et al., 2011)

ommatidium, with Scer\GAL4^ey.PU

(Choo et al., 2015)

Detailed Description

Statement

Reference

The expression of ND-75^KK108222 under the control of Scer\GAL4^ey.PU induces disruption to the patterning of ommatidia; a few eye discs exhibit overgrowths, which comprise both differentiated (neuronal, elav-marked) and mitotic cells.

(Choo et al., 2015)

Expression of ND75^KK108222 in the posterior signalling center (PSC) under the control of either Scer\GAL4^Antp-10 leads to an increase in the number of circulating lamellocytes.

(Sinenko et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ND-75^KK108222, Scer\GAL4^ey.PU has neoplasia | larval stage phenotype, enhanceable by Wwox^KK108459, Scer\GAL4^ey.PU

(Choo et al., 2015)

ND-75^KK108222, Scer\GAL4^ey.PU has abnormal neuroanatomy | larval stage phenotype, enhanceable by Wwox^KK108459, Scer\GAL4^ey.PU

(Choo et al., 2015)

ND-75^KK108222, Scer\GAL4^ey.PU has increased occurrence of cell division | larval stage phenotype, enhanceable by Wwox^KK108459, Scer\GAL4^ey.PU

(Choo et al., 2015)

NOT suppressed by

Statement

Reference

ND-75^KK108222, Scer\GAL4^Antp-10 has increased cell number | third instar larval stage phenotype, non-suppressible by bsk^DN.UAS, Scer\GAL4^Antp-10

(Sinenko et al., 2011)

ND-75^KK108222, Scer\GAL4^Antp-10 has increased cell number | third instar larval stage phenotype, non-suppressible by msn^UAS.cSa, Scer\GAL4^Antp-10

(Sinenko et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

ND-75^KK108222, Scer\GAL4^ey.PU has eye phenotype, enhanceable by Wwox^KK108459, Scer\GAL4^ey.PU

(Choo et al., 2015)

ND-75^KK108222, Scer\GAL4^ey.PU has eye disc phenotype, enhanceable by Wwox^KK108459, Scer\GAL4^ey.PU

(Choo et al., 2015)

ND-75^KK108222, Scer\GAL4^ey.PU has eye phenotype, enhanceable by Wwox^GD12175, Scer\GAL4^ey.PU

(Choo et al., 2015)

ND-75^KK108222, Scer\GAL4^ey.PU has eye phenotype, enhanceable by Wwox¹/Wwox[+]

(Choo et al., 2015)

Suppressed by

Statement

Reference

ND-75^KK108222, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by Wwox^UAS.cCa, Scer\GAL4^ey.PU

(Choo et al., 2015)

NOT suppressed by

Statement

Reference

ND-75^KK108222, Scer\GAL4^Antp-10 has lamellocyte | third instar larval stage phenotype, non-suppressible by bsk^DN.UAS, Scer\GAL4^Antp-10

(Sinenko et al., 2011)

ND-75^KK108222, Scer\GAL4^Antp-10 has lamellocyte | third instar larval stage phenotype, non-suppressible by msn^UAS.cSa, Scer\GAL4^Antp-10

(Sinenko et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of bsk^DN.Scer\UAS does not suppress the increase in circulating lamellocytes seen when ND75^KK108222 is expressed under the control of Scer\GAL4^Antp-10.

Expression of msn^Scer\UAS.cSa does not suppress the increase in circulating lamellocytes seen when ND75^KK108222 is expressed under the control of Scer\GAL4^Antp-10.

(Sinenko et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v100733

P{KK108222}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

ND-75^KDweak

(Granat et al., 2024)

ND-75^KK108222

(Granat et al., 2024)

ND75^KK108222

ND75^RNAi

(Choo et al., 2015)

RNAi_ND75

(Guitart et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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