FlyBase Allele Report: Dmel\TER94[UAS.cHa]

General Information

Symbol

Dmel\TER94^UAS.cHa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Higashiyama

FlyBase ID

FBal0240458

Feature type

allele

Associated gene

Dmel\TER94

Associated Insertion(s)

Carried in Construct

P{UAS-TER94.H}

Also Known As

UAS-ter94

Key Links

Transgenic product class

wild_type

(Higashiyama et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Higashiyama et al., 2002)

Mutagen

in vitro construct

(Higashiyama et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-TER94.H}

Cytology

Description

UAS regulatory sequences drive expression of the entire TER94 coding region, plus 110bp of 5' untranslated sequences and 560bp of 3' untranslated sequences.

(Higashiyama et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

TER94

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis

modeled by caz^VDRC.cUa

(Azuma et al., 2014)

exacerbates neurodegenerative disease

modeled by Zzzz\CAG^{Q92.GMR.Tag:FLAG}

(Higashiyama et al., 2002)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death, with Scer\GAL4^GMR.PS

(Higashiyama et al., 2002)

visible, with Scer\GAL4^GMR.PS

(Higashiyama et al., 2002)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PS

(Higashiyama et al., 2002)

interommatidial bristle, with Scer\GAL4^GMR.PS

(Higashiyama et al., 2002)

ommatidium, with Scer\GAL4^GMR.PS

(Higashiyama et al., 2002)

pigment cell, with Scer\GAL4^GMR.PS

(Higashiyama et al., 2002)

Detailed Description

Statement

Reference

The expression of TER94^UAS.cHa under the control of Scer\GAL4^elav.PLu does not lead to significant locomotive dysfunction in third instar larvae and adults, or obvious eye defects, as compared to controls.

(Jantrapirom et al., 2018)

There are no significant differences in total branch length between control larvae and larvae expressing Scer\GAL4^elav.PLu>TER94^Scer\UAS.cHa.

(Azuma et al., 2014)

Flies expressing one copy of TER94^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PS have a mild eye ablation phenotype, with a slight loss of red pigmentation, irregular ommatidial packing and missing interommatidial bristles.

Flies expressing two copies of TER94^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PS show considerable eye degeneration and have very small eyes. The external surface of the eye is glassy and less pigmented than normal.

Late pupal heads expressing TER94^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PS show massive apoptotic cell death in the compound eye cells.

(Higashiyama et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^elav.PLu/TER94^UAS.cHa is a suppressor of abnormal locomotor behavior | third instar larval stage phenotype of Scer\GAL4^elav.PLu, Ubqn^KK100857

(Jantrapirom et al., 2018)

Scer\GAL4^elav.PLu/TER94^UAS.cHa is a suppressor of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav.PLu, Ubqn^KK100857

(Jantrapirom et al., 2018)

Scer\GAL4^GMR.PS/TER94^UAS.cHa is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PS, caz^VDRC.cUa

(Azuma et al., 2014)

Scer\GAL4^elav.PLu/TER94^UAS.cHa is a suppressor of abnormal locomotor behavior | progressive phenotype of Scer\GAL4^elav.PLu, caz^VDRC.cUa

(Azuma et al., 2014)

Scer\GAL4^elav.PLu/TER94^UAS.cHa is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PS, caz^VDRC.cUa

(Azuma et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PS/TER94^UAS.cHa is a suppressor of eye phenotype of Scer\GAL4^GMR.PS, Ubqn^KK100857

(Jantrapirom et al., 2018)

Scer\GAL4^GMR.PS/TER94^UAS.cHa is a suppressor of eye phenotype of Scer\GAL4^GMR.PS, caz^VDRC.cUa

(Azuma et al., 2014)

Scer\GAL4^GMR.PS/TER94^UAS.cHa is a suppressor of ommatidium phenotype of Scer\GAL4^GMR.PS, caz^VDRC.cUa

(Azuma et al., 2014)

Scer\GAL4^GMR.PS/TER94^UAS.cHa is a suppressor of interommatidial bristle phenotype of Scer\GAL4^GMR.PS, caz^VDRC.cUa

(Azuma et al., 2014)

Scer\GAL4^elav.PLu/TER94^UAS.cHa is a suppressor of embryonic/larval motor neuron | larval stage phenotype of Scer\GAL4^elav.PLu, caz^VDRC.cUa

(Azuma et al., 2014)

Scer\GAL4^elav.PLu/TER94^UAS.cHa is a suppressor of NMJ bouton | larval stage phenotype of Scer\GAL4^elav.PLu, caz^VDRC.cUa

(Azuma et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of TER94^Scer\UAS.cHa suppresses the rough-eye phenotype induced by Scer\GAL4^GMR.PS>caz^VDRC.cUa.

Flies co-expressing TER94^Scer\UAS.cHa have significantly better climbing ability than do flies expressing Scer\GAL4^elav.PLu>caz^VDRC.cUa alone.

The decreased branch length phenotype caused by Scer\GAL4^elav.PLu>caz^VDRC.cUa in motor neurons is significantly enhanced by TER94^k15502/+.

Total branch length phenotype caused by Scer\GAL4^elav.PLu>caz^VDRC.cUa in motor neurons is significantly suppressed by the co-expression of TER94^Scer\UAS.cHa. The number of synaptic boutons is also significantly increased in Scer\GAL4^elav.PLu>caz^VDRC.cUa larvae co-expressing TER94^Scer\UAS.cHa compared with larvae expressing Scer\GAL4^elav.PLu>caz^VDRC.cUa alone.

(Azuma et al., 2014)

Xenogenetic Interactions

Statement

Reference

Expression of TER94^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PS enhances the rough eye phenotypes caused by Zzzz\CAG^{Q79.GMR.T:Zzzz\FLAG} or by Zzzz\CAG^{Q92.GMR.T:Zzzz\FLAG}.

(Higashiyama et al., 2002)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

TER94^Scer\UAS.cHa

TER94^UAS.cHa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Higashiyama

Secondary FlyBase IDs

References (3)

Report Sections

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