FB2024_03 , released June 25, 2024
Allele: Dmel\cryRNAi.UAS.cPa
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General Information
Symbol
Dmel\cryRNAi.UAS.cPa
Species
D. melanogaster
Name
FlyBase ID
FBal0240782
Feature type
allele
Associated gene
Dmel\cry
Associated Insertion(s)
Carried in Construct
P{UAS-cry.RNAi.P}
Also Known As
UAS-cryRNAi
Key Links
Transgenic product class
RNAi_reagent
(Picot et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Picot et al., 2007)
Mutagen
in vitro construct
(Picot et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-cry.RNAi.P}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat corresponding to the 300-799 region of the cry-RA transcript.

(Picot et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
cry
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  high grade glioma
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), btl::Egfrλ.UAS
      (Jarabo et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Similarly to wild-type animals, flies expressing Scer\GAL4P2.4.Pdf driven crydsRNA.Scer\UAS.cPa do not display locomotor activity rhythms under constant light conditions.

      In contrast to wild-type animals, flies expressing Scer\GAL80Pdf.PS and Scer\GAL4tim.PE driven crydsRNA.Scer\UAS.cPa do display locomotor activity rhythms under constant light conditions.

      In contrast to wild-type animals, the majority of flies expressing Scer\GAL4tim.PE driven crydsRNA.Scer\UAS.cPa show locomotor activity rhythms under constant light conditions.

      (Picot et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      WGMR.PG-induced ablation of the visual system results in rhythmic locomotory activity behaviour in flies expressing Scer\GAL4P2.4.Pdf driven crydsRNA.Scer\UAS.cPa under constant light conditions. Wild-type flies do not show rhythmic behavior under the same conditions.

      (Picot et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Expression of crydsRNA.Scer\UAS.cPa produces dsRNA which results in dsRNA interference (RNAi) of the cry gene.

      (Picot et al., 2007)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      cryRNAi.UAS.cPa
      crydsRNA.Scer\UAS.cPa
      crydsRNA.UAS.cPa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)