FlyBase Allele Report: Dmel\AP-2α[RNAi.UAS.cUa]

General Information

Symbol

Dmel\AP-2α^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0241094

Feature type

allele

Associated gene

Dmel\AP-2α

Associated Insertion(s)

Carried in Construct

P{UAS-AP-2α.RNAi.U}

Key Links

Transgenic product class

RNAi_reagent

(Raghu et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Raghu et al., 2009)

Mutagen

in vitro construct

(Raghu et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-AP-2α.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of a AP-2α RNAi construct.

(Raghu et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

AP-2α

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^109(2)80

(Yang et al., 2011)

Phenotype Manifest In

dendrite | larval stage, with Scer\GAL4^109(2)80

(Yang et al., 2011)

dendritic arborizing neuron | larval stage, with Scer\GAL4^109(2)80

(Yang et al., 2011)

eye photoreceptor cell, with Scer\GAL4^GMR.PF

(Raghu et al., 2009)

rhabdomere, with Scer\GAL4^GMR.PF

(Raghu et al., 2009)

Detailed Description

Statement

Reference

The number of dendritic endpoints of dorsal dendritic arborisation neurons is reduced compared to controls in larvae expressing α-Adaptin^{dsRNA.Scer\UAS.cUa} under the control of Scer\GAL4^109(2)80.

(Yang et al., 2011)

Expression of α-Adaptin^{dsRNA.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PF disrupts rhabdomere development; individual rhabdomeres are smaller than normal and ill formed, the base of the rhabdomeres is distorted and the cell bodies of the photoreceptor cells show accumulation of membraneous structures.

(Raghu et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Animals co-expressing both Pld^Scer\UAS.cRa and α-Adaptin^{dsRNA.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PF have virtually no detectable rhabdomeres, and the cell bodies of the photoreceptors continue to show accumulation of membrane transport intermediates.

(Raghu et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

AP-2α^RNAi.UAS.cUa

AP-2α^{dsRNA.Scer\UAS.cUa}

AP-2α^{dsRNA.UAS.cUa}

α-Adaptin^{dsRNA.Scer\UAS.cUa}

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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