FB2024_03 , released June 25, 2024
Allele: Dmel\Ilp641
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General Information
Symbol
Dmel\Ilp641
Species
D. melanogaster
Name
FlyBase ID
FBal0241437
Feature type
allele
Associated gene
Dmel\Ilp6
Associated Insertion(s)
Carried in Construct
Also Known As
dilp641
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Slaidina et al., 2009)
Delta2-3 transposase
(Grönke et al., 2010)
Progenitor genotype
P{SUPor-P}RafKG04972
(Grönke et al., 2010)
Caused by aberration
Df(1)Ilp641
Cytology
Description

Breakpoint of Df(1)Ilp641, in which the 5' upstream region and first exon of Ilp6 is removed, though the full Ilp6 ORF is intact.

(Grönke et al., 2010)

Imprecise excision of a progenitor insertion has resulted in a deletion that removes the first exon and part of the first intron of Ilp6.

(Slaidina et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ilp641 homozygous mutant third instar larvae present decreased numbers of abdominal lateral and dorsal, but not ventral, adult muscle precursor cells, as compared to controls.

      (Aradhya et al., 2015)

      Mutant adults show a reduction in mass compared to controls.

      Mutant wandering stage larvae have normal levels of circulating carbohydrates and of triacylglycerides.

      The growth of Ilp641 adults is compromised relative to that of control animals upon starvation (the mutant adults show a greater reduction of mass under starvation conditions compared to standard feeding conditions than do control adults).

      (Slaidina et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Ilp641 is rescued by Scer\GAL4Cg.PA/Ilp6UAS.cIa

      (Slaidina et al., 2009)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      DILP6#41
      (Slaidina et al., 2009)
      Df(Ilp6)
      (Aradhya et al., 2015)
      Dilp641
      (Chatterjee et al., 2014)
      Ilp641
      (Fernandes et al., 2017)
      Ilp6[41]
      (Cong et al., 2015)
      dilp641
      (Cho et al., 2018, Liu et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)