FB2024_03 , released June 25, 2024
Allele: Dmel\DCTN1-p150Δ.UASp
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General Information
Symbol
Dmel\DCTN1-p150Δ.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0241637
Feature type
allele
Associated gene
Dmel\DCTN1-p150
Associated Insertion(s)
Carried in Construct
P{UASp-DCTN1-p150.Δ}
Also Known As
UASp-ΔGl
Key Links
Transgenic product class
dominant_negative_variant
(Boylan et al., 2008)
inframe_deletion
(Mische et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Boylan et al., 2008)
inframe_deletion
(Mische et al., 2007)
Mutagen
in vitro construct
(Mische et al., 2007)
Progenitor genotype
Carried in construct
P{UASp-DCTN1-p150.Δ}
Cytology
Description

Dominant negative Gl construct.

(Boylan et al., 2008)

UASp regulatory sequences drive expression of DCTN1-p150, based on the original DCTN1-p1501 mutation.

(Mische et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
DCTN1-p150
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Potassium-induced unloading of FM1-43 from neuromuscular junction boutons (pre-loaded into an internalised vesicle population during stimulation) is defective in animals expressing the dominant negative GlΔ.Scer\UAS.P\T under the control of Scer\GAL4VGlut-OK371.

      (Li et al., 2010)

      Expression of GlΔ.Scer\UAS.P\T under the control of two copies of Scer\GAL4Act5C results in small, rough eyes with disruptions in the hexagonal packing of the ommatidia.

      (Iyadurai et al., 2008)

      Cytoplasmic streaming in the oocyte is unaffected by expression of GlΔ.Scer\UAS.P\T under the control of Scer\GAL4nos.UTR.T:Hsim\VP16.

      (Mische et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The rough eye phenotype caused by expression of GlΔ.Scer\UAS.P\T under the control of two copies of Scer\GAL4Act5C is significantly suppressed by coexpression of spis.Scer\UAS.

      (Iyadurai et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DCTN1-p150Δ.Scer\UAS.P\T
      DCTN1-p150Δ.UASp
      GlΔ.Scer\UAS.P\T
      Name Synonyms
      Secondary FlyBase IDs
        References (6)