FlyBase Allele Report: Dmel\hth[JF02733]

General Information

Symbol

Dmel\hth^JF02733

Species

D. melanogaster

Name

FlyBase ID

FBal0242316

Feature type

allele

Associated gene

Dmel\hth

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02733}

Also Known As

UAS-hth^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02733}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02733

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval optic lobe | third instar larval stage, with Scer\GAL4^esg-MH766, Scer\GAL80^ey.3.5

(Apitz and Salecker, 2016)

Detailed Description

Statement

Reference

Expression of hth^JF02733 under the control of Scer\GAL4^esg-MH766 combined with Scer\GAL80^ey.3.5 leads to significantly reduced volume of neuroblast/ganglion mother cell clusters in the outer proliferation centre of brain optic lobes in third instar larvae.

(Apitz and Salecker, 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

hth^JF02733/Scer\GAL4^Bx-MS1096 is a suppressor | partially of visible phenotype of Scer\GAL4^Bx-MS1096, hng1^KK103642

(Shukla et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

hth^JF02733/Scer\GAL4^Bx-MS1096 is a suppressor | partially of wing hinge phenotype of Scer\GAL4^Bx-MS1096, hng1^KK103642

(Shukla et al., 2014)

hth^JF02733/Scer\GAL4^Bx-MS1096 is a suppressor | partially of wing phenotype of Scer\GAL4^Bx-MS1096, hng1^KK103642

(Shukla et al., 2014)

hth^JF02733/Scer\GAL4^Bx-MS1096 is a suppressor | partially of alula phenotype of Scer\GAL4^Bx-MS1096, hng1^KK103642

(Shukla et al., 2014)

NOT Suppressor of

Statement

Reference

hth^JF02733/Scer\GAL4^tin.CΔ4 is a non-suppressor of adult heart phenotype of Scer\GAL4^tin.CΔ4, yki^{S168A.UAS.Tag:V5}

(Yu et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of hth^JF02733 does not suppress the cardiac hypertrophy seen when yki^{S168A.Scer\UAS.T:SV5\V5} is expressed under the control of Scer\GAL4^tin.CΔ4.

(Yu et al., 2015)

Expression of hth^JF02733 suppresses the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096. The size and patterning of the alula is also rescued.

(Shukla et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27655

y¹ v¹; P{TRiP.JF02733}attP2/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

hth^JF02733

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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