FlyBase Allele Report: Dmel\ASPP[d]

General Information

Symbol

Dmel\ASPP^d

Species

D. melanogaster

Name

FlyBase ID

FBal0242642

Feature type

allele

Associated gene

Dmel\ASPP

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage (with ASPP⁸)

(Bertran et al., 2019)

increased cell number | adult stage (with ASPP⁸)

(Bertran et al., 2019)

increased cell number | pupal stage (with ASPP⁸)

(Bertran et al., 2019)

visible | adult stage (with ASPP⁸)

(Bertran et al., 2019)

Phenotype Manifest In

interommatidial bristle | pupal stage (with ASPP⁸)

(Bertran et al., 2019)

interommatidial cell | pupal stage (with ASPP⁸)

(Bertran et al., 2019)

scutellar bristle | increased number (with ASPP⁸)

(Bertran et al., 2019)

wing (with ASPP⁸)

(Bertran et al., 2019)

Detailed Description

Statement

Reference

ASPP^d/ASPP⁸ transheterozygotes exhibit significantly more inter-ommatidial cells and frequently misplaced bristles in the pupal eye, as well as larger wings and frequent duplication of scutellar bristles in adults.

(Bertran et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ASPP^d/ASPP⁸, Csk^j1D8 has visible | adult stage phenotype, suppressible by ASPP^Ubi-p63E.GFP

(Bertran et al., 2019)

ASPP^d/ASPP⁸, Csk^j1D8 has visible | adult stage phenotype, suppressible | partially by ASPP^{FA.Ubi-p63E.GFP}

(Bertran et al., 2019)

Enhancer of

Statement

Reference

ASPP^{KVK.Ubi-p63E.GFP}, ASPP^d, ASPP⁸ is an enhancer of increased cell number | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^{WK.Ubi-p63E.GFP}, ASPP^d, ASPP⁸ is an enhancer of increased cell number | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^d, ASPP^{FA-WK.Ubi-p63E.GFP}, ASPP⁸ is an enhancer of increased cell number | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^d/ASPP⁸ is an enhancer of increased cell number | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^d, ASPP^{FA.Ubi-p63E.GFP}, ASPP⁸ is an enhancer of increased cell number | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

NOT Enhancer of

Statement

Reference

ASPP^Ubi-p63E.GFP, ASPP^d, ASPP⁸ is a non-enhancer of increased cell number | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^d/ASPP[+] is a non-enhancer of visible | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

NOT Suppressor of

Statement

Reference

ASPP^d/ASPP[+] is a non-suppressor of visible | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

Other

Statement

Reference

ASPP^d/ASPP⁸, Csk^j1D8 has visible | adult stage phenotype

(Bertran et al., 2019)

ASPP^d, Csk^j1D8 has visible phenotype

(Langton et al., 2009)

ASPP^d, arm³/arm[+] has visible phenotype

(Langton et al., 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

ASPP^d/ASPP⁸, Csk^j1D8 has wing phenotype, suppressible by ASPP^Ubi-p63E.GFP

(Bertran et al., 2019)

ASPP^d/ASPP⁸, Csk^j1D8 has wing phenotype, suppressible | partially by ASPP^{FA.Ubi-p63E.GFP}

(Bertran et al., 2019)

Enhancer of

Statement

Reference

ASPP^d, ASPP^{FA.Ubi-p63E.GFP}, ASPP⁸ is an enhancer of interommatidial bristle | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^{KVK.Ubi-p63E.GFP}, ASPP^d, ASPP⁸ is an enhancer of interommatidial cell | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^{KVK.Ubi-p63E.GFP}, ASPP^d, ASPP⁸ is an enhancer of interommatidial bristle | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^{WK.Ubi-p63E.GFP}, ASPP^d, ASPP⁸ is an enhancer of interommatidial cell | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^{WK.Ubi-p63E.GFP}, ASPP^d, ASPP⁸ is an enhancer of interommatidial bristle | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^d, ASPP^{FA-WK.Ubi-p63E.GFP}, ASPP⁸ is an enhancer of interommatidial cell | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^d, ASPP^{FA-WK.Ubi-p63E.GFP}, ASPP⁸ is an enhancer of interommatidial bristle | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^d/ASPP⁸ is an enhancer of eye | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^d/ASPP⁸ is an enhancer of interommatidial bristle | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^d, ASPP^{FA.Ubi-p63E.GFP}, ASPP⁸ is an enhancer of interommatidial cell | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

NOT Enhancer of

Statement

Reference

ASPP^Ubi-p63E.GFP, ASPP^d, ASPP⁸ is a non-enhancer of interommatidial cell | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^Ubi-p63E.GFP, ASPP^d, ASPP⁸ is a non-enhancer of interommatidial bristle | pupal stage phenotype of Df(2L)Exel7014/Ccdc85^C1.1

(Bertran et al., 2019)

ASPP^d/ASPP[+] is a non-enhancer of eye | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

NOT Suppressor of

Statement

Reference

ASPP^d/ASPP[+] is a non-suppressor of eye | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

Other

Statement

Reference

ASPP^d/ASPP⁸, Csk^j1D8 has wing phenotype

(Bertran et al., 2019)

ASPP^d, Csk^j1D8 has wing phenotype

(Langton et al., 2009)

ASPP^d, arm³/arm[+] has eye phenotype

(Langton et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

ASPP^d/ASPP⁸, Csk^j1D8/+ adults very frequently show wing notches, which are never observed in controls; this phenotype is fully rescued by ASPP^Ubi-p63E.GFP, but only partially by ASPP^{FA.Ubi-p63E.GFP}.

(Bertran et al., 2019)

The rough eye phenotype observed in adults expressing Magi^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^GMR.PU is not modified by combination with single copy of ASPP^d.

(Zaessinger et al., 2015)

68% of ASPP^d ; Csk^j1D8/+ flies have notched wings.

arm³/+ ; ASPP^d/ASPP^d flies have enlarged eyes.

(Langton et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ASPP^d/ASPP⁸ is rescued by ASPP^Ubi-p63E.GFP

(Bertran et al., 2019)

Partially rescued by

ASPP^d/ASPP⁸ is partially rescued by ASPP^{FA.Ubi-p63E.GFP}

(Bertran et al., 2019)

ASPP^d/ASPP⁸ is partially rescued by ASPP^{KVK.Ubi-p63E.GFP}

(Bertran et al., 2019)

ASPP^d/ASPP⁸ is partially rescued by ASPP^{FA-WK.Ubi-p63E.GFP}

(Bertran et al., 2019)

Comments

ASPP^d/ASPP⁸ transheterozygotes show increased numbers of inter-ommatidial cells and misplaced bristles in the pupal eye, as well as the enlarged wings in adults, all of which are fully rescued by ASPP^Ubi-p63E.GFP but only partially rescued by ASPP^{FA.Ubi-p63E.GFP}, ASPP^{KVK.Ubi-p63E.GFP}, ASPP^{FA-WK.Ubi-p63E.GFP}, or ASPP^{WK.Ubi-p63E.GFP}. ASPP^d/ASPP⁸ transheterozygotes also show duplicated scutellar bristles, which are fully and partially suppressed in males and females, respectively, by ASPP^Ubi-p63E.GFP, and partially suppressed in both males and females by ASPP^{FA.Ubi-p63E.GFP}.

(Bertran et al., 2019)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ASPP^d

(Bertran et al., 2019, Zaessinger et al., 2015)

dASPP^d

(Langton et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (3)

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