FlyBase Allele Report: Dmel\L[fee]

General Information

Symbol

Dmel\L^fee

Species

D. melanogaster

Name

freaky eye

FlyBase ID

FBal0242925

Feature type

allele

Associated gene

Dmel\L

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Wang and Huang, 2009)

Mutagen

spontaneous

(Wang and Huang, 2009)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size

(Wang and Huang, 2009)

abnormal size (with L^rev6-3)

(Wang and Huang, 2009)

viable

(Wang and Huang, 2009)

visible

(Wang and Huang, 2009)

visible (with L^rev6-3)

(Wang and Huang, 2009)

Phenotype Manifest In

eye

(Wang and Huang, 2009)

eye (with L^rev6-3)

(Wang and Huang, 2009)

Detailed Description

Statement

Reference

Most L^fee adult eyes are smaller than wildtype. The eyes have a nick at the anterior border of the eye, and often extra hairs and rod-like tissue are observed in this region. Overgrowth of eye tissue is occasionally observed.

L^fee/L^rev6-3 trans-heterozygotes have smaller eyes than L^fee alone.

(Wang and Huang, 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

L^fee has abnormal size phenotype, enhanceable by Scer\GAL4^ey.PH/upd1^UAS.cZa

(Wang and Huang, 2009)

L^fee has abnormal size phenotype, enhanceable by mTor^{WT.UAS.Tag:FLAG}/Scer\GAL4^ey.PH

(Wang and Huang, 2009)

L^fee has abnormal size phenotype, enhanceable by S6k[+]/S6k⁰⁷⁰⁸⁴

(Wang and Huang, 2009)

L^fee has abnormal size phenotype, enhanceable by Hsap\CDKN1A^UAS.cHa/Scer\GAL4^ey.PH

(Wang and Huang, 2009)

Suppressed by

Statement

Reference

L^fee has abnormal size phenotype, suppressible by dome^ΔCYT.UAS/Scer\GAL4^ey.PH

(Wang and Huang, 2009)

L^fee has abnormal size phenotype, suppressible by Myc^UAS.cZa/Scer\GAL4^ey.PH

(Wang and Huang, 2009)

L^fee has visible phenotype, suppressible by Df(1)os¹/+

(Wang and Huang, 2009)

L^fee has abnormal size phenotype, suppressible by Df(1)os¹/os[+]

(Wang and Huang, 2009)

L^fee has abnormal size phenotype, suppressible by Stat92E^F/Stat92E⁰⁶³⁴⁶

(Wang and Huang, 2009)

NOT suppressed by

Statement

Reference

L^fee has abnormal size phenotype, non-suppressible by Scer\GAL4^ey.PH/CycE^UAS.cLa

(Wang and Huang, 2009)

L^fee has abnormal size phenotype, non-suppressible by hh[+]/hh^bar3

(Wang and Huang, 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

L^fee has eye phenotype, enhanceable by Scer\GAL4^ey.PH/upd1^UAS.cZa

(Wang and Huang, 2009)

L^fee has eye phenotype, enhanceable by mTor^{WT.UAS.Tag:FLAG}/Scer\GAL4^ey.PH

(Wang and Huang, 2009)

L^fee has eye phenotype, enhanceable by S6k[+]/S6k⁰⁷⁰⁸⁴

(Wang and Huang, 2009)

L^fee has eye phenotype, enhanceable by Hsap\CDKN1A^UAS.cHa/Scer\GAL4^ey.PH

(Wang and Huang, 2009)

Suppressed by

Statement

Reference

L^fee has eye phenotype, suppressible by Df(1)os¹/+

(Wang and Huang, 2009)

L^fee has eye phenotype, suppressible by Df(1)os¹/os[+]

(Wang and Huang, 2009)

L^fee has eye phenotype, suppressible by Stat92E^F/Stat92E⁰⁶³⁴⁶

(Wang and Huang, 2009)

L^fee has eye phenotype, suppressible by dome^ΔCYT.UAS/Scer\GAL4^ey.PH

(Wang and Huang, 2009)

L^fee has eye phenotype, suppressible by Myc^UAS.cZa/Scer\GAL4^ey.PH

(Wang and Huang, 2009)

NOT suppressed by

Statement

Reference

L^fee has eye phenotype, non-suppressible by Scer\GAL4^ey.PH/CycE^UAS.cLa

(Wang and Huang, 2009)

L^fee has eye phenotype, non-suppressible by hh[+]/hh^bar3

(Wang and Huang, 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Eye size is restored in Df(1)os¹/+; L^fee animals.

Eye size is almost restored to normal in L^fee; Stat92E⁰⁶³⁴⁶/Stat92E^F animals.

Expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^ey.PH in a L^fee mutant background restores eye size to normal.

Expression of upd1^Scer\UAS.cZa under the control of Scer\GAL4^ey.PH in a L^fee mutant background exacerbates the L^fee phenotype, resulting in eyeless heads.

Expression of CycE^Scer\UAS.cLa under the control of Scer\GAL4^ey.PH in a L^fee mutant background does not restore eye size.

Expression of Tor^{WT.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^ey.PH in a L^fee background enhances the reduction in eye size observed in L^fee animals.

L^fee; S6k⁰⁷⁰⁸⁴/+ flies have a reduced eye size compared to L^fee flies.

Expression of dm^Scer\UAS.cZa under the control of Scer\GAL4^ey.PH in a L^fee background significantly restores eye size.

The reduced eye size of L^fee flies is not restored by hh^bar3/+.

(Wang and Huang, 2009)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\CDKN1A^Scer\UAS.cHa under the control of Scer\GAL4^ey.PH in a L^fee mutant background does not restore eye size, and flies have small eyes.

(Wang and Huang, 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

L^fee

(Wang and Huang, 2009)

fee

(Wang and Huang, 2009)

Name Synonyms

freaky eye

(Wang and Huang, 2009)

Secondary FlyBase IDs

References (1)

Report Sections

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