FB2024_03 , released June 25, 2024
Allele: Dmel\picok1
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General Information
Symbol
Dmel\picok1
Species
D. melanogaster
Name
FlyBase ID
FBal0243031
Feature type
allele
Associated gene
Dmel\pico
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Lyulcheva et al., 2008)
Progenitor genotype
P{GSV6}picoGS9133
(Lyulcheva et al., 2008)
Cytology
Description

2.81 kb deletion removes the 5' end of pico-L isoform and a large region upstream of the predicted pico start site.

(Lyulcheva et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:19,848,691..19,851,501 [-]
Comment:

Estimated endpoints of 2.81 kb deletion resulting from the imprecise excision of P{GSV6}picoGS9133. The deletion extends from the insertion into the pico gene.

(Lyulcheva et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous picok1 larvae are dramatically reduced in size, with severely reduced endoreplicated tissue and little or no detectable imaginal disc tissue. Larvae die following an extended larval period of up to 2 weeks.

      Somatic clones of picok1 in the wing disc are not readily detected. Mutant clones contain an average of 5 cells, and are found localised to the basal surface of the wing imaginal disc.

      Reduced tissue growth resulting from ectopic expression of picoScer\UAS.T:Avic\GFP-EGFP in the wing by Scer\GAL4Bx-MS1096 is enhanced by removing one copy of picok1.

      (Lyulcheva et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      picok1
      (Lyulcheva et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)