FB2024_03 , released June 25, 2024
Allele: Dmel\beP1
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General Information
Symbol
Dmel\beP1
Species
D. melanogaster
Name
FlyBase ID
FBal0243156
Feature type
allele
Associated gene
Dmel\be
Associated Insertion(s)
P{lacW}beP1
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{lacW}beP1
    Cytology
    Description

    P{lacW}beP1 is inserted 21 bp 5' of the CG32594 transcriptional start site.

    (Zhao et al., 2009)
    Allele components
    Component
    Use(s)
    Inserted element
    P{lacW}
    Encoded product / tool
    lacZ
    Tagged with
    Tag:NLS(P)
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        In beP1 homozygotes and beP1/beEY08069 adults, long-term memory resulting from Pavlovian olfactory learning tested 1 day after spaced training (10 training sessions with a 15 minute rest between each) is significantly impaired. However, no effect is seen on long term memory tested 1 day after massed training (10 training sessions with no intervals) or on the rate of memory loss after after a single training session.

        Recordings from a neuro-muscular junction (muscle 12, segment 3 or 4) show that while the mean amplitude of spontaneous mini excitatory junction currents (EJCs) is normal in beP1/+ animals, the mean amplitude of evoked EJCs is significantly lower than normal (by nearly 35%), consistent with a drop in quantal content to ~65% of wild-type. The synaptic structure at neuro-muscular junctions appears to be normal in these animals.

        (Zhao et al., 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Other
        Statement
        Reference

        Scamp[+]/ScampEP1593, beP1 has abnormal memory | recessive phenotype

        (Zhao et al., 2009)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        In beP1/ScampEP1593 adults, long-term memory resulting from Pavlovian olfactory learning tested 1 day after spaced training (10 training sessions with a 15 minute rest between each) is significantly impaired. However, no effect is seen on long term memory tested 1 day after massed training (10 training sessions with no intervals) or on the rate of memory loss after after a single training session. This phenotype is not seen in beP1/+ or ScampEP1593/+ animals.

        Recordings from a neuro-muscular junction (muscle 12, segment 3 or 4) show that while the mean amplitude of spontaneous mini excitatory junction currents (EJCs) is normal in beP1/ScampEP1593 animals, the mean amplitude of evoked EJCs is significantly lower than normal. This phenotype is not seen in beP1/+ or ScampEP1593/+ animals.

        (Zhao et al., 2009)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        mRNA levels of be are reduced, but those of hiw and CG5541 or normal. The long term memory phenotype is reverted by precise excision of P{lacW}beP1

        (Zhao et al., 2009)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        20816039
        (Zhao et al., 2009)
        beP1
        benP1
        (Zhao et al., 2009)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)