FB2024_03 , released June 25, 2024
Allele: Dmel\beUAS.cZa
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General Information
Symbol
Dmel\beUAS.cZa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct of Zhao
FlyBase ID
FBal0243159
Feature type
allele
Associated gene
Dmel\be
Associated Insertion(s)
Carried in Construct
P{UAS-ben.Z}
Key Links
Transgenic product class
cDNA
(Zhao et al., 2009)
wild_type
(Zhao et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Zhao et al., 2009)
wild_type
(Zhao et al., 2009)
Mutagen
in vitro construct
(Zhao et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-ben.Z}
Cytology
Description

UASt regulatory sequences drive expression of a be cDNA (SD04373).

(Zhao et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
be
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      beUAS.cZa/Scer\GAL4hs.PB rescues beP1

      (Zhao et al., 2009)

      Scer\GAL4Mef2.247/beUAS.cZa rescues beP1

      (Zhao et al., 2009)

      beUAS.cZa/Scer\GAL4c739 rescues beP1

      (Zhao et al., 2009)

      Scer\GAL4c305a/beUAS.cZa rescues beP1

      (Zhao et al., 2009)
      Fails to rescue

      Scer\GAL4Feb170/beUAS.cZa fails to rescue beP1

      (Zhao et al., 2009)
      Comments

      beScer\UAS.cZa (insertion P{UAS-ben.Z}4-8) Scer\GAL4hs.PB rescues the long term memory defects seen in beP1/Y adults if a 45 minute heat shock is applied 3 hours before training. No rescue is seen if the heat shock is applied 3 hours before testing, instead of before training. beScer\UAS.cZa (insertion P{UAS-ben.Z}4-8) Scer\GAL4hs.PB also rescues the reduction in evoked excitatory junction currents seen at neuromuscular junctions in beP1/Y larvae.

      beScer\UAS.cZa Scer\GAL4247; Scer\GAL80ts.alphaTub84B rescues the long term memory defects seen in beP1/Y adults if the training and testing is done at 30'C (non-permissive temperature for Scer\GAL80ts.alphaTub84B) but not at 18'C (permissive temperature for Scer\GAL80ts.alphaTub84B). The same results are seen if other mushroom body drivers are used - Scer\GAL4c739 or Scer\GAL4c305a - in place of Scer\GAL4247. In contrast if the ellipsoid body driver Scer\GAL4Feb170 is used, no rescue is seen.

      (Zhao et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      beScer\UAS.cZa
      beUAS.cZa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct of Zhao
      Secondary FlyBase IDs
        References (1)