FB2024_03 , released June 25, 2024
Allele: Dmel\Prp31NIG.6876R
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General Information
Symbol
Dmel\Prp31NIG.6876R
Species
D. melanogaster
Name
FlyBase ID
FBal0243550
Feature type
allele
Associated gene
Dmel\Prp31
Associated Insertion(s)
Carried in Construct
P{NIG.6876R}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ray et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ray et al., 2010)
Mutagen
in vitro construct
(Ray et al., 2010)
Progenitor genotype
Carried in construct
P{NIG.6876R}
Cytology
Description

UASt regulatory sequences drive expression of a Prp31 RNAi construct.

(Ray et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-6876R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  retinitis pigmentosa
      CEA
      (Ray et al., 2010)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Prp31NIG.6876R under the control of Scer\GAL4ey.PU have eyes which are either smaller in size than normal and abnormal in shape or are completely absent (approximately 90% of these flies have some kind of eye defect). The flies show extensive signs of neurodegeneration in the intra-ommatidial space around the rhabdomeres, with significant reduction in the sizes of the rhabdomeres. Loss of pigment cells and the presence of multi-vesicular bodies and autophagic vacuoles is also seen in the eye.

      (Ray et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Prp31NIG.6876R, Scer\GAL4ey.PU has visible phenotype, suppressible | partially by Hsap\PRPF31GMR.GFP

      (Ray et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The eye neurodegeneration defects seen in flies expressing Prp31NIG.6876R under the control of Scer\GAL4ey.PU are partially rescued if they also express either Hsap\PRPF31GMR.T:Avic\GFP or Hsap\PRPF31AD5.GMR.T:Avic\GFP. The external eye defects seen in flies expressing Prp31NIG.6876R under the control of Scer\GAL4ey.PU are partially rescued if they also express Hsap\PRPF31GMR.T:Avic\GFP.

      (Ray et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Prp31NIG.6876R
      Name Synonyms
      Secondary FlyBase IDs
        References (2)