FB2024_03 , released June 25, 2024
Allele: Dmel\Ilp2UAS.cZa
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General Information
Symbol
Dmel\Ilp2UAS.cZa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Zhang
FlyBase ID
FBal0243953
Feature type
allele
Associated gene
Dmel\Ilp2
Associated Insertion(s)
Carried in Construct
P{UAS-Ilp2.Z}
Key Links
Transgenic product class
cDNA
(Zhang et al., 2009)
wild_type
(Zhang et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Zhang et al., 2009)
wild_type
(Zhang et al., 2009)
Mutagen
in vitro construct
(Zhang et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Ilp2.Z}
Cytology
Description

UAS regulatory sequences drive expression of a Ilp2 cDNA.

(Zhang et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Ilp2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Ilp2UAS.cZa/Scer\GAL4hs.PB partially rescues Df(3L)Ilp1-5

      (Zhang et al., 2009)
      Comments

      Expression of Scer\GAL4hs.PB-driven Ilp2Scer\UAS.cZa is sufficient to rescue the growth defects of Df(3L)dilp1-5 homozygotes. The developmental delay associated with Df(3L)dilp1-5 homozygotes is largely rescued upon Ilp2Scer\UAS.cZa expression, with homozygotes reaching the wandering third-instar larval stage after 6 days.

      The decreased cell size in the fat body of homozygous Df(3L)dilp1-5 mutants is rescued by expression of Ilp2Scer\UAS.cZa driven by Scer\GAL4hs.PB.

      The starvation phenotype in the fat body of homozygous Df(3L)dilp1-5 mutants is partially rescued by expression of Ilp2Scer\UAS.cZa driven by Scer\GAL4hs.PB.

      Expression of Ilp2Scer\UAS.cZa driven by Scer\GAL4hs.PB rescues the elevated circulating sugar level phenotype of homozygous Df(3L)dilp1-5 larvae.

      (Zhang et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ilp2Scer\UAS.cZa
      Ilp2UAS.cZa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Zhang
      Secondary FlyBase IDs
        References (1)