FB2024_03 , released June 25, 2024
Allele: Dmel\nAChRα6O
Open Close
General Information
Symbol
Dmel\nAChRα6O
Species
D. melanogaster
Name
FlyBase ID
FBal0244385
Feature type
allele
Associated gene
Dmel\nAChRα6
Associated Insertion(s)
pogo{}nAChRα6O
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    pogo{}nAChRα6O
    Caused by aberration
    In(2LR)O
    Cytology
    Description

    Inversion breakpoint (30D1 breakpoint of In(2LR)O) is within an intron of nAChRα6. The 5' (distal) end of this breakpoint corresponds to 2L:9 ,805,567 and the 3' (proximal) end corresponds to 2L:9 ,805,575 (release 6 coordinates), meaning that 7bp of genomic sequence is deleted at this breakpoint.

    (Miller et al., 2018)

    One of the inversions of the In(2LR)O chromosome fuses nAcRα-30D sequence from exon 8b (cytologically located at 30D) to the 5' end of Prosap (cytologically located at 50C). An internally deleted remnant of a pogo transposable element is also present on the nAcRα-30D side of the inversion.

    (Perry et al., 2007)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        nAcRα-30DO in transheterozygous combination with one of nAcRα-30DCB1, nAcRα-30DCB2, nAcRα-30DCB3, nAcRα-30DCB4, nAcRα-30DCB5, nAcRα-30DCB6, nAcRα-30DCB7, nAcRα-30DCB8, nAcRα-30DCB9nAcRα-30DCB10, nAcRα-30DCB11, nAcRα-30DCB12, nAcRα-30DCB13 or nAcRα-30DCB14 results in adults which are resistant to spinosyn A compared to controls.

        (Watson et al., 2010)

        nAcRα-30DO/Df(2L)s1402 animals are 1181-fold resistant to the insecticide spinosad compared to wild-type (susceptible) controls.

        Heterozygotes show a 1.7-fold increased resistance to the insecticide spinosad compared to wild-type (susceptible) controls.

        (Perry et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        nAChRα6O
        (Miller et al., 2018)
        nAcRα-30DO
        nAcRα-30DO
        (Watson et al., 2010)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)