FB2024_03 , released June 25, 2024
Allele: Dmel\Madm2D2
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General Information
Symbol
Dmel\Madm2D2
Species
D. melanogaster
Name
FlyBase ID
FBal0245112
Feature type
allele
Associated gene
Dmel\Madm
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Mushtaq et al., 2022)
Mutagen
ethyl methanesulfonate
(Gluderer et al., 2010)
Progenitor genotype
Cytology
Description

A deletion causes a frame-shift after amino acid residue 385, resulting in a premature stop codon after an additional 34 amino acids.

(Gluderer et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Madm2D2/Madm2D2 mutant intestinal stem cell clones have significantly fewer cells and a smaller size than control clones.

      (Nie et al., 2015)

      Madm2D2 mutants exhibit a small head (pinhead) phenotype.

      Development of Madm2D2 mutant larvae ceases mostly in the third larval instar and in the pre-pupal stage. The onset of the pre-pupal stage is delayed by 2 to 10 days. Madm2D2 mutants lead to strong growth deficits, most apparent in L3 larvae.

      (Gluderer et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Based on the severity of the pinhead phenotype, when the mutant is over Df(3R)Exel7283, the following Madm alleles can be ranked from the most severe to the weakest: Madm2D2 = Madm2U3 = Madm3G5 > Madm3Y2 = Madm4S3 = Madm7L2 > Madm3T4.

      (Gluderer et al., 2010)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Madm2D2
      (Mushtaq et al., 2022, Nie et al., 2015, Gluderer et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)