An genomic fragment containing the entire HLH106 gene and upstream sequences, carrying a D386A mutation.
HLH106[+]/SREBP189, SREBPD386A/SREBPD386A is an enhancer of lethal | larval stage phenotype of S2PKG08356/S2P1
SREBPD386A, SREBPD386A, SREBP189, SREBP189 is an enhancer of lethal | larval stage phenotype of S2PKG08356/S2P1
HLH106[+]/SREBP189, SREBPD386A/SREBPD386A is a non-suppressor of viable | conditional phenotype of S2PKG08356/S2P1
SREBPD386A, SREBPD386A, SREBP189, SREBP189 is a non-suppressor of viable | conditional phenotype of S2PKG08356/S2P1
On unsupplemented medium, S2PKG08356/S2P1 mutants in the presence of two copies of HLH106D386A and carrying HLH106189/+, survive at less than 25% of the expected rate. When these animals are homozygous for HLH106189, survival at only 10% of the expected rate is observed. Survival is restored by supplementing the culture medium with free fatty acids.