FB2024_03 , released June 25, 2024
Allele: Dmel\raptorJF01088
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General Information
Symbol
Dmel\raptorJF01088
Species
D. melanogaster
Name
FlyBase ID
FBal0245407
Feature type
allele
Associated gene
Dmel\raptor
Associated Insertion(s)
Carried in Construct
P{TRiP.JF01088}
Also Known As
UAS-Raptor RNAi, UAS-RaptorRNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
in vitro construct
(Ni et al., 2008)
Progenitor genotype
Carried in construct
P{TRiP.JF01088}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF01088
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing raptorJF01088 under the control of Scer\GAL4en.PU leads to more cells undergoing S-phase and mitosis in the posterior compartment of the wing disc (where Scer\GAL4en.PU is driving expression), as compared to controls.

      (Li et al., 2019)

      Expression under the control of Scer\GAL4eya.enh1+E+2 results in a misshapen eye phenotype.

      (Pletcher et al., 2019)

      Expression of raptorJF01088 in cardiac muscle under the control of Scer\GAL4GMR88D05 has no effect on pupal eclosion rates.

      Expression of raptorJF01088 in skeletal muscle under the control of Scer\GAL4how-24B results in lethality.

      Expression of raptorJF01088 under the control of Scer\GAL4c179 causes partial lethality. The number of pupae formed does not differ from controls. Many of the surviving flies have a reduced climbing rate compared with controls.

      Expression of raptorJF01088 under the control of Scer\GAL4Mef2.PR is lethal. The number of pupae formed does not differ from controls.

      Expression of raptorJF01088 under the control of Scer\GAL4Mhc.F3-580 has no effect on pupal eclosion rates and the adult flies do not exhibit any significant climbing defects. Lifespan is reduced compared with controls.

      (Hatfield et al., 2015)

      Expression of raptorJF01088 RNAi under either Scer\GAL4VGlut-OK371 or Scer\GAL4elav-C155 results in a significant decrease in the number of neuromuscular junction boutons in third instar larvae compared to controls.

      (Wong et al., 2015)

      Expression of raptorJF01088 under the control of Scer\GAL4Myo31DF-NP0001 results in premature autophagy in the larval midgut and shortened gastric caeca at an early age, 4 hrs before puparium formation.

      Expression of raptorJF01088 under the control of Scer\GAL4cg.PU results in a lack of autophagic difference in the larval fat body between fed and starved flies as compared to controls.

      (Xu et al., 2015)

      Scer\GAL4Ilp2.PR-mediated expression results in a significant reduction in the body weight of emerging adults compared to controls.

      (Hasygar and Hietakangas, 2014)

      The neuromuscular junction in larvae expressing raptorJF01088 under the control of Scer\GAL4elav.PLu (co-expressed with Dcr-2) do not have a significantly different number of synaptic boutons from controls. However a decrease is seen in bouton size.

      (Natarajan et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      raptorJF01088
      Name Synonyms
      Secondary FlyBase IDs
        References (13)