FlyBase Allele Report: Dmel\Hrb98DE[JF01249]

General Information

Symbol

Dmel\Hrb98DE^JF01249

Species

D. melanogaster

Name

FlyBase ID

FBal0245541

Feature type

allele

Associated gene

Dmel\Hrb98DE

Associated Insertion(s)

Carried in Construct

P{TRiP.JF01249}

Also Known As

Hrp38^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

(Ni et al., 2008)

Progenitor genotype

Carried in construct

P{TRiP.JF01249}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF01249

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodegenerative disease

CEA

(Romano et al., 2014)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neurodegenerative disease

modeled by TBPH^GD6943, TBPH^Δ23

(Romano et al., 2014)

modeled by Zzzz\CGG^90.UAS.EGFP

(He et al., 2014)

ameliorates neurodegenerative disease

modeled by TBPH^UAS.Tag:FLAG

(Appocher et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

(Romano et al., 2014)

short lived, with Scer\GAL4^elav.PU

(Romano et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Hrb98DE^JF01249 under the control of Scer\GAL4^GMR.PU has no obvious effect on adult eye morphology.

(Appocher et al., 2017)

Expression of Hrb98DE^JF01249 under the control of Scer\GAL4^elav.PU leads to significant climbing defects and a severe reduction in life span, as compared to controls.

(Romano et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hrb98DE^JF01249, Scer\GAL4^elav.PU has abnormal locomotor behavior | adult stage phenotype, enhanceable by TBPH[+]/TBPH^Δ23

(Romano et al., 2014)

Hrb98DE^JF01249, Scer\GAL4^elav.PU has short lived phenotype, enhanceable by TBPH[+]/TBPH^Δ23

(Romano et al., 2014)

Hrb98DE^JF01249, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23 has abnormal locomotor behavior | adult stage phenotype, enhanceable by TBPH^GD6943, Scer\GAL4^elav.PU

(Romano et al., 2014)

Hrb98DE^JF01249, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23 has short lived phenotype, enhanceable by TBPH^GD6943, Scer\GAL4^elav.PU

(Romano et al., 2014)

Hrb98DE^JF01249, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23 has abnormal neuroanatomy | adult stage phenotype, enhanceable by TBPH^GD6943, Scer\GAL4^elav.PU

(Romano et al., 2014)

Enhancer of

Statement

Reference

Hrb98DE^JF01249, Scer\GAL4^elav.PU is an enhancer of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^GD6943

(Romano et al., 2014)

Hrb98DE^JF01249, Scer\GAL4^elav.PU is an enhancer of short lived phenotype of Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^GD6943

(Romano et al., 2014)

Hrb98DE^JF01249, Scer\GAL4^elav.PU is an enhancer of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^GD6943

(Romano et al., 2014)

Suppressor of

Statement

Reference

Hrb98DE^JF01249, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG

(Appocher et al., 2017)

Hrb98DE^JF01249, Scer\GAL4^GMR.PU is a suppressor | partially of melanotic mass phenotype | adult stage phenotype of Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG

(Appocher et al., 2017)

Hrb98DE^JF01249, Scer\GAL4^GMR.PU is a suppressor | partially of abnormal eye color phenotype of Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG

(Appocher et al., 2017)

Other

Statement

Reference

Hrb98DE^JF01249, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23 has abnormal neuroanatomy | adult stage phenotype

(Romano et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hrb98DE^JF01249, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23 has neuropil | adult stage phenotype, enhanceable by TBPH^GD6943, Scer\GAL4^elav.PU

(Romano et al., 2014)

Enhancer of

Statement

Reference

Hrb98DE^JF01249, Scer\GAL4^elav.PU is an enhancer of neuropil | adult stage phenotype of Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^GD6943

(Romano et al., 2014)

Suppressor of

Statement

Reference

Hrb98DE^JF01249, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG

(Appocher et al., 2017)

Hrb98DE^JF01249, Scer\GAL4^GMR.PU is a suppressor | partially of ommatidium | adult stage phenotype of Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG

(Appocher et al., 2017)

Other

Statement

Reference

Hrb98DE^JF01249, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23 has neuropil | adult stage phenotype

(Romano et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The eye degeneration phenotype (appearance of melanotic spots, fusion of ommatidia) characteristic for adult flies expressing TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.PU is strongly suppressed by co-expression of Hrb98DE^JF01249.

(Appocher et al., 2017)

TBPH^Δ23/+ enhances the climbing defects and and shortened life span seen in flies expressing Hrb98DE^JF01249 under the control of Scer\GAL4^elav.PU.

Flies expressing Hrb98DE^JF01249 under the control of Scer\GAL4^elav.PU in a TBPH^Δ23/+ background exhibit degeneration of the neuropil.

Expression of TBPH^GD6943 under the control of Scer\GAL4^elav.PU further enhances the climbing defects, shortened life span and neuropil degeneration seen in TBPH^Δ23/+ flies expressing Hrb98DE^JF01249 under the control of Scer\GAL4^elav.PU.

Co-expression of Hrb98DE^JF01249 enhances the climbing defects, shortened life span and neuropil degeneration seen in TBPH^Δ23/+ flies expressing TBPH^GD6943 under the control of Scer\GAL4^elav.PU.

(Romano et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

31303

y¹ v¹; P{TRiP.JF01249}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hrb98DE^JF01249

Hrp38^RNAi

(Appocher et al., 2017, Romano et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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