UAS regulatory sequences drive expression of an inverted repeat.
eye, with Scer\GAL4ey.PH
Flies expressing HDAC1JF01401 under the control of Scer\GAL4fat exhibit significantly shorter survival time under starvation stress, as compared to controls.
Expression of HDAC1JF01401 results in: small and rough adult eye phenotype (with Scer\GAL4ey.PH), held out wings with vein defects (with Scer\GAL4nub.PK), missing as well as ectopic wing veins (with Scer\GAL4en.PU) expression controlled by Scer\GAL4GMR.PF has no overt adult phenotype.
Expression of HDAC1JF01401 under the control of Scer\GAL4Act.PU results in lethality.
Expression of HDAC1JF01401 under the control of Scer\GAL4arm.PU leads to increased lifespan and increased survival to paraquat-induced oxidative stress, as compared to controls.
Expression of HDAC1JF01401 under the control of Scer\GAL4tin.CΔ4 in males leads to increased survival to paraquat-induced oxidative stress, starvation, or heat stress, as compared to controls; in females, the same expression leads to increased survival to paraquat-induced oxidative stress and starvation, but not to heat stress.
Adults expressing HDAC1JF01401 under the control of Scer\GAL4tin.CΔ4 display increased heart rate under either control conditions (no stress), paraquat-induced oxidative stress or heat stress, as compared to wild-type controls; expression of HDAC1JF01401 under the control of Scer\GAL4tin.CΔ4 increases the heart recovery rate and decreases the heart failure rate after electric shocks in animals under paraquat-induced oxidative stress, as compared to equally stressed controls; this expression of HDAC1JF01401 under the control of Scer\GAL4tin.CΔ4 has no significant effect in the overall lifespan, as compared to controls.
Expression of HDAC1JF01401 under the control of Scer\GAL4r4 is semi-lethal in males and does not improve survival under paraquat-induced oxidative stress in adult females, as compared to wild-type controls.
Expression of HDAC1JF01401 under the control of Scer\GAL4GMR.PU in adult does not increase survival to paraquat-induced oxidative stress; it does not increase the heart rate or decrease the heart failure rate after electric shock; it also does not have an obvious effect on the eye morphology.
Expression of HDAC1JF01401 under the control of both Scer\GAL4GMR.PU and Scer\GAL4Scer\UAS.cHa improves survival to paraquat-induced oxidative stress and increases the lifespan and heart rate under control conditions (absence of stress), as compared to wild-type control animals.
HDAC1JF01401, Scer\GAL4ey.PH has visible | adult stage phenotype, enhanceable by httGD14943, Scer\GAL4ey.PH
HDAC1JF01401, Scer\GAL4nub.PK has visible | adult stage phenotype, enhanceable by httGD14943, Scer\GAL4nub.PK
HDAC1JF01401, Scer\GAL4ey.PH has visible | adult stage phenotype, enhanceable by httint
HDAC1JF01401, Scer\GAL4nub.PK has visible | adult stage phenotype, enhanceable by httint
HDAC1JF01401, Scer\GAL4ey.PH has eye phenotype, enhanceable by httGD14943, Scer\GAL4ey.PH
HDAC1JF01401, Scer\GAL4nub.PK has wing blade phenotype, enhanceable by httGD14943, Scer\GAL4nub.PK
HDAC1JF01401, Scer\GAL4ey.PH has eye phenotype, enhanceable by httint
HDAC1JF01401, Scer\GAL4nub.PK has wing blade phenotype, enhanceable by httint
The eye or wing phenotype induced by expression of HDAC1JF01401 under the control of either Scer\GAL4ey.PH or Scer\GAL4nub.PK, respectively, is weakly enhanced by combination with httint or by co-expression of httGD14943.
