FB2024_03 , released June 25, 2024
Allele: Dmel\Rab23T69A
Open Close
General Information
Symbol
Dmel\Rab23T69A
Species
D. melanogaster
Name
FlyBase ID
FBal0246043
Feature type
allele
Associated gene
Dmel\Rab23
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

antimorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    antimorphic allele - genetic evidence

    (Pataki et al., 2010)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Rab23T69A is semi-lethal, but homozygous mutant animals occasionally survive till adulthood and display a strong multiple wing hair phenotype as well as hair orientation defects. Whereas hair orientation is only mildly affected in the submarginal and 1st posterior cells, the deflection from wild-type orientation is more obvious the rest of the wing.

        Hemizygous Rab23T69A/Df(3R)BSC47 mutants display wing hair phenotypes including multiple hairs and hair orientation defects.

        Clones of Rab23T69A mutant cells in the pupal wing display delayed pre-hair initiation cell autonomously.

        Some of the Rab23T69A mutant pupal wing cells display impaired hexagonal packing at around 30-32 h after puparium formation (APF). In wild-type wings, the ratio of non-hexagonally shaped cells relative to hexagonally shaped cells is around 11%, whereas in Rab23T69A homozygous mutant wings this ratio increases to 27%. The formation of multiple wing hairs does not appear to correlate with irregular cell shape in the pupal wing.

        Rab2351/Rab23T69A mutants exhibit a multiple wing hair phenotype.

        (Pataki et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        Rab2351/Rab23T69A has visible phenotype, enhanceable by in1/in[+]

        (Pataki et al., 2010)
        Enhancer of
        Statement
        Reference

        Rab23[+]/Rab23T69A is an enhancer of visible | heat sensitive phenotype of fzhs.PP

        (Pataki et al., 2010)
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        Rab2351/Rab23T69A has wing hair phenotype, enhanceable by in1/in[+]

        (Pataki et al., 2010)
        Enhancer of
        Statement
        Reference

        Rab23[+]/Rab23T69A is an enhancer of wing hair | heat sensitive phenotype of fzhs.PP

        (Pataki et al., 2010)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        in1 dominantly enhances the number of multiple hairs in certain regions of Rab2351/Rab23T69A mutant wings.

        Rab23T69A dominantly enhances the multiple hair phenotype induced by late fzhs.PP overexpression.

        (Pataki et al., 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Rab23T69A is rescued by Scer\GAL4Act5C.PU/Rab23UASp.YFP

        (Pataki et al., 2010)

        Rab23T69A is rescued by Rab23+t12.3

        (Pataki et al., 2010)
        Comments

        A single copy of Rab23+t12.3 rescues the wing hair phenotypes of both Rab23T69A and Rab2351.

        Expression of Scer\GAL4Act5C.PU-driven Rab23Scer\UAS.P\T.T:Avic\GFP-YFP rescues the wing hair phenotypes of Rab23T69A.

        (Pataki et al., 2010)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Rab23T69A
        (Pataki et al., 2010)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)