FlyBase Allele Report: Dmel\fz[hs.PP]

General Information

Symbol

Dmel\fz^hs.PP

Species

D. melanogaster

Name

heat shock construct of Park

FlyBase ID

FBal0049593

Feature type

allele

Associated gene

Dmel\fz

Associated Insertion(s)

Carried in Construct

P{hs-fz}

Also Known As

hs-fz

Key Links

Transgenic product class

cDNA

(Park et al., 1994)

wild_type

(Park et al., 1994)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Park et al., 1994)

wild_type

(Park et al., 1994)

Mutagen

in vitro construct

(Park et al., 1994)

Progenitor genotype

Carried in construct

P{hs-fz}

Cytology

Description

Expression of a fz cDNA is driven by an Hsp70 promoter.

(Park et al., 1994)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Rousset et al., 2001)

abnormal planar polarity | heat sensitive

(Lee and Adler, 2002)

visible | heat sensitive

(Pataki et al., 2010)

Phenotype Manifest In

wing

(Rousset et al., 2001)

wing hair

(Chae et al., 1999, Taylor et al., 1998)

wing hair | heat sensitive

(Pataki et al., 2010, Lee and Adler, 2002)

Detailed Description

Statement

Reference

Late overexpression of fz^hs.PP induces multiple wing hairs.

(Pataki et al., 2010)

When hot wax is applied to the wing tip - causing a gradient of fz activity - wing hairs show reversed polarity and point distal-to-proximal. When expressed late, just prior to hair initiation in pupae a multiple hair cell phenotype results.

(Lee and Adler, 2002)

Induces wing cells to form multiple wing hairs.

(Chae et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

fz^hs.PP has visible | heat sensitive phenotype, enhanceable by Rab23[+]/Rab23^T69A

(Pataki et al., 2010)

fz^hs.PP has visible | heat sensitive phenotype, enhanceable by Rab23[+]/Rab23⁵¹

(Pataki et al., 2010)

Suppressed by

Statement

Reference

fz^hs.PP has abnormal planar polarity | heat sensitive phenotype, suppressible by fy²

(Lee and Adler, 2002)

fz^hs.PP has abnormal planar polarity phenotype, suppressible by nkd^UAS.Tag:MYC/Scer\GAL4^hs.PB

(Rousset et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

fz^hs.PP has wing hair | heat sensitive phenotype, enhanceable by Rab23[+]/Rab23^T69A

(Pataki et al., 2010)

fz^hs.PP has wing hair | heat sensitive phenotype, enhanceable by Rab23[+]/Rab23⁵¹

(Pataki et al., 2010)

fz^hs.PP has wing hair | heat sensitive phenotype, enhanceable by dsh^hs.PA

(Lee and Adler, 2002)

fz^hs.PP has wing hair | heat sensitive phenotype, enhanceable by in^hs.PP

(Lee and Adler, 2002)

fz^hs.PP has wing hair phenotype, enhanceable by stan³

(Chae et al., 1999)

Suppressed by

Statement

Reference

fz^hs.PP has wing hair | heat sensitive phenotype, suppressible by fy²

(Lee and Adler, 2002)

fz^hs.PP has wing phenotype, suppressible by nkd^UAS.Tag:MYC/Scer\GAL4^hs.PB

(Rousset et al., 2001)

NOT suppressed by

Statement

Reference

fz^hs.PP has wing hair | heat sensitive phenotype, non-suppressible by fy⁶

(Lee and Adler, 2002)

fz^hs.PP has wing hair | heat sensitive phenotype, non-suppressible by in¹/in^II53

(Lee and Adler, 2002)

Enhancer of

Statement

Reference

fz^hs.PP is an enhancer of wing hair phenotype of fy⁶

(Lee and Adler, 2002)

fz^hs.PP is an enhancer of wing hair & 1st posterior cell phenotype of in^II53

(Lee and Adler, 2002)

Other

Statement

Reference

Vang^unspecified, fz^hs.PP has wing hair phenotype

(Taylor et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Rab23^T69A dominantly enhances the multiple hair phenotype induced by late fz^hs.PP overexpression.

Rab23⁵¹ dominantly enhances the multiple hair phenotype induced by late fz^hs.PP overexpression.

(Pataki et al., 2010)

Late gain of function phenotype of fz^hs.PP is not suppressible by in^II53/in¹ or fy⁶.

(Lee and Adler, 2002)

The addition of nkd^{Scer\UAS.T:Hsap\MYC} and Scer\GAL4^hs.PB completely suppresses the wing hair polarity phenotype seen in fz^hs.PP flies.

The addition of nkd^Scer\UAS.cZa and Scer\GAL4^hs.PB completely suppresses the wing hair polarity phenotype seen in fz^hs.PP flies.

(Rousset et al., 2001)

stan³ does not block the ability of fz^hs.PP to form multiple hairs, it rather enhances the fz^hs.PP multiple hair phenotype slightly.

(Chae et al., 1999)

When expressed just before prehair initiation, in a Vang mutant background, cells are still induced to form multiple hairs. Indeed, the Vang mutant background slightly enhances the formation of multiple hairs. Vang function is required for the ability of a gradient of fz expression (induced by distal waxing) to repolarize wing hairs.

(Taylor et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Carried in a plasmid and transfected into S2 cells.

(Yun et al., 1999)

Carried in plasmid "hs-fz" and expressed in Schneider cells.

(Park et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fz^hs.PP

Name Synonyms

heat shock construct of Park

(Park et al., 1994)

Secondary FlyBase IDs

References (8)

Report Sections

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