FlyBase Allele Report: Scer\GAL4[NP2426]

General Information

Symbol

Scer\GAL4^NP2426

Species

S. cerevisiae

Name

FlyBase ID

FBal0246283

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

P{GawB}Sxl^NP2426

Carried in Construct

Also Known As

NP2426, Gal4-LN2, LN2-Gal4, NP2426-GAL4, LN2Gal4

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{GawB}Sxl^NP2426

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage -- wandering third instar larval stage

GABAergic local interneuron of larval antennal lobe | subset

(Thum et al., 2011)

larval gnathal ganglion

(Thum et al., 2011)

adult stage

adult antennal lobe local neuron | subset

Comment: 37 per antennal lobe

(Acebes et al., 2011, Das et al., 2008)

GABAergic local interneuron of the adult antennal lobe | subset

(Das et al., 2008)

cholinergic local interneuron of the adult antennal lobe | subset

(Das et al., 2008)

adult antennal lobe local neuron lLN2

(Tanaka et al., 2012)

adult local interneuron of the ventral ALv2 neuroblast

(Tanaka et al., 2012)

antennal lobe hub | restricted

(Tanaka et al., 2012)

Additional Information

Statement

Reference

Drives adult expression in around 40 type B local interneurons, including a subset of GABAergic local interneurons of the adult antennal lobe. Drives larval expression in a subset of GABAergic local interneuron of the larval antennal lobe.

(FlyBase Curators, 2017)

ScerGAL4^Sxl-NP2426 drives expression in around 40 type B local interneurons. Their cell bodies cluster in the dorso-lateral region of the antennal lobe and project to all antennal lobe glomeruli and the antennal lobe hub. An additional three interneurons with ventrally located cell bodies are labeled. These project to antennal lobe glomeruli VA5, VA4, VL2a, VM1, VM6, VP1, VP2 and VP3.

(Tanaka et al., 2012)

ScerGAL4^Sxl-NP2426 drives expression in six to eight neurons that innervate the larval antennal lobe (AL) and the subesophageal ganglion. Innervation pattern becomes increasingly dense during larval development. The cell bodies of two to three labeled neurons are located in a cluster ventrolateral to the AL. The other four to five cell bodies are located dorsolateral to the AL.

(Thum et al., 2011)

ScerGAL4^NP2426 is expressed in 37 local neurons of the antennal lobe.

(Acebes et al., 2011)

The approximately 40 somata of cells expressing ScerGAL4^NP2426 are predominantly found in a lateral cell body cluster of the antennal lobe, with a few located in a ventral cell body cluster.

(Das et al., 2008)

Marker for

Reflects expression of

Sxl

(Tanaka et al., 2012, Thum et al., 2011, Das et al., 2008)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References