β-Specem6 mutants expressing β-SpecM.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav-C155 are short lived compared to controls.
Nervous system expression of β-SpecM.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav-C155 is sufficient to allow a high rate of survival of β-Specem6 males. Reared at 25[o]C, male progeny appear somewhat unhealthy with crumpled wings, rough eyes, small size and are short-lived. Nevertheless, these males are fertile and thus represent a significant rescue of embryonic lethality. At a reduced temperature (22[o]C), the level of β-SpecScer\UAS.T:Hsap\MYC expression is reduced and the appearance of the rescued flies is closer to wild-type (i.e. wings are properly unfolded and the thorax and abdomen are full-size).