FB2024_03 , released June 25, 2024
Allele: Dmel\mir-312UAS.cluster.cTa
Open Close
General Information
Symbol
Dmel\mir-312UAS.cluster.cTa
Species
D. melanogaster
Name
FlyBase ID
FBal0247623
Feature type
allele
Associated gene
Dmel\mir-312
Associated Insertion(s)
Carried in Construct
P{UAS-miR310s}
Also Known As
UAS-Dm310s
Key Links
Transgenic product class
wild_type
(Tang et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tang et al., 2010)
Mutagen
in vitro construct
(Tang et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-miR310s}
Cytology
Description

UAS regulatory sequences drive expression of a cluster composed of mir-310, mir-311, mir-312 and mir-313.

(Tang et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
mir-312
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of P{UAS-miR310s} driven by Scer\GAL4Act5C.PI results in complete lethality.

      Expression of P{UAS-miR310s} driven by Scer\GAL4NP5941 results in about 60% lethality.

      Expression of P{UAS-miR310s} driven by Scer\GAL4DJ715 results in about 55% lethality.

      (Tang et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      mir-312UAS.cluster.cTa rescues Df(2R)Dm310s

      (Liufu et al., 2017)
      Comments

      The deformed dorsal appendages of Df(2R)Dm310s mutant eggs along with their reduced hatchability as well as the decreased fertility of Df(2R)Dm310s mutant males is rescued by combination with the P{UAS-miR310s} construct carrying a cluster of 'mir310s' - mir-310, mir-311, mir-312 and mir-313 - under UAS control and includes the mir-312Scer\UAS.cluster.cTa allele.

      (Liufu et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      mir-312Scer\UAS.cTa
      mir-312Scer\UAS.cluster.cTa
      mir-312UAS.cluster.cTa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)