FB2024_03 , released June 25, 2024
Allele: Dmel\wrdKO1
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General Information
Symbol
Dmel\wrdKO1
Species
D. melanogaster
Name
FlyBase ID
FBal0248457
Feature type
allele
Associated gene
Dmel\wrd
Associated Insertion(s)
TI{TI}wrdKO1
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
site specific recombination
(Hahn et al., 2010)
ends-out gene targeting
(Hahn et al., 2010)
Progenitor genotype
Associated Insertion(s)
TI{TI}wrdKO1
Cytology
Description

The first exon of wrd has been replaced by a w+mW.hs marker flanked by loxP sites. This results in a shift in the reading frame of the remaining exons.

(Hahn et al., 2010)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PP2A-B'KO1 mutant adult flies are leaner than wild-type flies and display a significantly reduced life span compared to controls.

      (Hahn et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      wrdKO1 has short lived phenotype, suppressible | partially by S6k[+]/S6k07084

      (Hahn et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      S6k07084/+ significantly rescues the lean-fly phenotype of PP2A-B'KO1 mutants, and partially rescues the decreased life span of PP2A-B'KO1 mutant flies.

      (Hahn et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      wrdKO1 is rescued by wrdUAS.Tag:FLAG/Scer\GAL4hs.PB

      (Hahn et al., 2010)
      Comments

      Expression of PP2A-B'Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4hs.PB rescues the shorter life-span and lean body composition of PP2A-B'KO1 mutant flies.

      (Hahn et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PP2A-B'KO1
      (Hahn et al., 2010)
      wrdK01
      (Neal et al., 2022)
      wrdKO1
      (Neal et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)