FlyBase Allele Report: Dmel\Syn2[37]

General Information

Symbol

Dmel\Syn2³⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0248508

Feature type

allele

Associated gene

Dmel\Syn2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Nagai et al., 2010)

Mutagen

Delta2-3 transposase

(Nagai et al., 2010)

Progenitor genotype

P{GT1}BG01762

(Nagai et al., 2010)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 3019bp deletion.

(Nagai et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage

(Nagai et al., 2010)

viable

(Nagai et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes do not show a change in median lifespan compared to controls.

Homozygous flies show moderately reduced mobility in a climbing assay compared to wild-type controls.

Mutant larvae do not have any apparent changes in neuromuscular junction morphology.

(Nagai et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Syn2³⁷ has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^Act5C.PU/Syn1^NIG.7152R

(Nagai et al., 2010)

Enhancer of

Statement

Reference

Syn2³⁷ is an enhancer of partially lethal - majority die phenotype of Scer\GAL4^Act5C.PU, Syn1^NIG.7152R

(Nagai et al., 2010)

Other

Statement

Reference

Nsf2^EQ.UAS, Scer\GAL4^elav.PLu, Syn2³⁷ has abnormal neuroanatomy | third instar larval stage phenotype

(Nagai et al., 2010)

Nsf2^EQ.UAS, Scer\GAL4^elav.PLu, Syn2³⁷ has abnormal locomotor behavior | third instar larval stage phenotype

(Nagai et al., 2010)

Nsf2^EQ.UAS, Scer\GAL4^elav.PLu, Syn1^NIG.7152R, Syn2³⁷ has abnormal neuroanatomy | third instar larval stage phenotype

(Nagai et al., 2010)

Nsf2^EQ.UAS, Scer\GAL4^elav.PLu, Syn1^NIG.7152R, Syn2³⁷ has abnormal locomotor behavior | third instar larval stage phenotype

(Nagai et al., 2010)

Scer\GAL4^Act5C.PU, Syn1^NIG.7152R, Syn2³⁷ has short lived phenotype

(Nagai et al., 2010)

Phenotype Manifest In

Other

Statement

Reference

Nsf2^EQ.UAS, Scer\GAL4^elav.PLu, Syn2³⁷ has embryonic/larval neuromuscular junction phenotype

(Nagai et al., 2010)

Nsf2^EQ.UAS, Scer\GAL4^elav.PLu, Syn1^NIG.7152R, Syn2³⁷ has embryonic/larval neuromuscular junction phenotype

(Nagai et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

The viability of animals expressing Syn1^NIG.7152R under the control of Scer\GAL4^Act5C.PU in a Syn2³⁷ background is reduced to 13.8%. The double mutant flies pupate and develop into pharate adults that do not show any apparent morphological defects, but the majority do not hatch. Some flies manage to protrude their heads out of the pupal case, but are not able to eclose fully and eventually die.

Flies expressing Syn1^NIG.7152R under the control of Scer\GAL4^Act5C.PU in a Syn2³⁷ background have a median lifespan of 27 days, significantly shorter than that of wild-type controls.

Flies expressing Syn1^NIG.7152R under the control of Scer\GAL4^Act5C.PU in a Syn2³⁷ background have a strongly reduced mobility in a climbing assay compared to wild-type controls, especially in older animals.

Larvae expressing Syn1^NIG.7152R under the control of Scer\GAL4^Act5C.PU in a Syn2³⁷ background do not have any apparent changes in neuromuscular junction morphology.

Larvae expressing Nsf2^EQ.Scer\UAS under the control of Scer\GAL4^elav.PLu in a Syn2³⁷ background show a dramatic increase in total synaptic branch length at the neuromuscular junction. These larvae show a reduced frequency of peristaltic waves compared to wild type.

Larvae co-expressing Nsf2^EQ.Scer\UAS and Syn1^NIG.7152R under the control of Scer\GAL4^elav.PLu in a Syn2³⁷ background show a very dramatic increase in total synaptic branch length at the neuromuscular junction. These larvae show a reduced frequency of peristaltic waves compared to wild type.

(Nagai et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Syn2³⁷

(Nagai et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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