FlyBase Allele Report: Dmel\ebi[P7]

General Information

Symbol

Dmel\ebi^P7

Species

D. melanogaster

Name

FlyBase ID

FBal0249412

Feature type

allele

Associated gene

Dmel\ebi

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Dong et al., 1999)

Mutagen

P-element activity

(Dong et al., 1999)

Progenitor genotype

ebi^k16213

(Dong et al., 1999)

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response (with ebi^E90)

(Lim et al., 2012)

abnormal size (with ebi^2g1)

(Marygold et al., 2011)

abnormal size (with ebi^CC3)

(Marygold et al., 2011)

abnormal size (with ebi^E4)

(Marygold et al., 2011)

abnormal size (with ebi^k16213)

(Marygold et al., 2011)

abnormal size (with ebi^W418X)

(Marygold et al., 2011)

abnormal size (with ebi^Δ1)

(Marygold et al., 2011)

female semi-sterile | recessive

(Dong et al., 1999)

lethal (with ebi^2g1)

(Marygold et al., 2011)

lethal (with ebi^2g2)

(Marygold et al., 2011)

lethal (with ebi^CC3)

(Marygold et al., 2011)

lethal (with ebi^CCS-8)

(Marygold et al., 2011)

lethal (with ebi^E90)

(Marygold et al., 2011)

partially lethal - majority die (with ebi^E4)

(Marygold et al., 2011)

partially lethal - majority die (with ebi^k16213)

(Marygold et al., 2011)

partially lethal - majority die (with ebi^W418X)

(Marygold et al., 2011)

partially lethal - majority die (with ebi^Δ1)

(Marygold et al., 2011)

viable

(Marygold et al., 2011)

viable (with ebi^WKS-24)

(Marygold et al., 2011)

visible | recessive

(Dong et al., 1999)

Phenotype Manifest In

cone cell (with ebi^E4)

(Tsuda et al., 2002)

embryo

(Dong et al., 1999)

eye

(Dong et al., 1999)

macrochaeta

(Dong et al., 1999)

macrochaeta | ectopic (with ebi^W418X)

(Marygold et al., 2011)

wing (with ebi^2g1)

(Marygold et al., 2011)

wing (with ebi^CC3)

(Marygold et al., 2011)

wing (with ebi^E4)

(Marygold et al., 2011)

wing (with ebi^k16213)

(Marygold et al., 2011)

wing (with ebi^W418X)

(Marygold et al., 2011)

wing (with ebi^Δ1)

(Marygold et al., 2011)

wing pouch (with ebi^2g1)

(Marygold et al., 2011)

wing pouch (with ebi^2g2)

(Marygold et al., 2011)

wing pouch (with ebi^CC3)

(Marygold et al., 2011)

wing pouch (with ebi^E4)

(Marygold et al., 2011)

wing pouch (with ebi^W418X)

(Marygold et al., 2011)

wing vein

(Dong et al., 1999)

Detailed Description

Statement

Reference

ebi^P7/ebi^E90 escaper flies are more sensitive to paraquat treatment than controls.

(Lim et al., 2012)

ebi^P7/ebi^2g1 wings are 72% the size of control wings. Wing cell size is reduced. Gross defects in wing patterning are not apparent.

The wing pouch of ebi^P7/ebi^2g1 larval wing discs is reduced to about a quarter of its normal size.

ebi^P7/ebi^E4 wings are 86% the size of control wings. Gross defects in wing patterning are not apparent. There is no significant decrease in the size of other organs or the whole organism.

ebi^P7/ebi^E4 larval wing discs have visibly smaller wing pouches.

ebi^P7/ebi^Δ1 wings are 84% the size of control wings. Wing cell size is unaffected - the wing size reduction is the result of fewer cells. Gross defects in wing patterning are not apparent. There is no significant decrease in the size of other organs or the whole organism.

ebi^P7/ebi^W418X wings are 83% the size of control wings. Wing cell size is unaffected - the wing size reduction is the result of fewer cells. Gross defects in wing patterning are not apparent. There is no significant decrease in the size of other organs or the whole organism.

ebi^P7/ebi^W418X larval wing discs have visibly smaller wing pouches.

ebi^P7/ebi^k16213 wings are 82% the size of control wings. Gross defects in wing patterning are not apparent. There is no significant decrease in the size of other organs or the whole organism.

ebi^P7/ebi^CC3 males occasionally show an overall reduction in body size, but their wings are still disproportionately small.

The wing pouch of ebi^P7/ebi^CC3 larval wing discs is reduced to about a quarter of its normal size.

The wing pouch of ebi^P7/ebi^2g2 larval wing discs is reduced to about a quarter of its normal size.

Macrochaetes on ebi^P7/ebi^W418X nota are stunted and form in ectopic positions.

(Marygold et al., 2011)

In ebi^E4/ebi⁷ animals at the non-permissive temperature a loss of cone cells is seen.

(Tsuda et al., 2002)

ebi^P7/ebi^E90 flies are viable and show phenotypes similar to weak loss of function Egfr alleles including partial female sterility resulting from partially ventralized eggs, wing vein defects, short bristles and rough eyes.

(Dong et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ebi^E90/ebi^P7 has abnormal oxidative stress response phenotype, suppressible by Jra¹/Jra[+]

(Lim et al., 2012)

Enhancer of

Statement

Reference

ebi[+]/ebi^P7 is an enhancer of abnormal size phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Marygold et al., 2011)

NOT Enhancer of

Statement

Reference

ebi[+]/ebi^P7 is a non-enhancer of abnormal size phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Marygold et al., 2011)

Phenotype Manifest In

Suppressed by

Statement

Reference

ebi^E4/ebi^P7 has cone cell phenotype, suppressible by Delta^UAS.cDa/Scer\GAL4^elav.PLu

(Tsuda et al., 2002)

Enhancer of

Statement

Reference

ebi[+]/ebi^P7 is an enhancer of wing phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Marygold et al., 2011)

NOT Enhancer of

Statement

Reference

ebi[+]/ebi^P7 is a non-enhancer of wing vein phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Marygold et al., 2011)

ebi[+]/ebi^P7 is a non-enhancer of wing margin phenotype of sd^ETX4

(Marygold et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for ebi^P7 enhances the small wing phenotype induced by Scer\GAL4^Bx-MS1096-mediated expression of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}.

(Marygold et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ebi^E4/ebi^P7 is rescued by ebi^UAS.cTa/Scer\GAL4^elav.PLu

(Tsuda et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Weak allele.

(Dong et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ebi⁷

(Lim et al., 2012)

ebi^P7

(Lim et al., 2012)

ebi^p7

(Tsuda et al., 2006)

Name Synonyms

Secondary FlyBase IDs

FBal0096970
FBal0141146

References (6)

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