FB2024_03 , released June 25, 2024
Allele: Scer\GAL4Gr61a.4.9
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General Information
Symbol
Scer\GAL4Gr61a.4.9
Species
S. cerevisiae
Name
FlyBase ID
FBal0249502
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{Gr61a-GAL4.4.9}
Also Known As
Gr61a-GAL4
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Weiss et al., 2011, Dahanukar et al., 2007)
Progenitor genotype
Carried in construct
P{Gr61a-GAL4.4.9}
Cytology
Description

A 4.9kb Gr61a promoter fragment is fused upstream of sequence encoding a GAL4 driver.

(Weiss et al., 2011)

Approximately 5kb of Gr61a promoter fragment is fused upstream of sequence encoding a GAL4 driver.

(Dahanukar et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
Gr61a
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      sugar-sensing neuron of taste bristle | subset of prothoracic tarsal segment 2
      (Ling et al., 2014)
      sugar-sensing neuron of taste bristle | subset of prothoracic tarsal segment 3
      (Ling et al., 2014)
      sugar-sensing neuron of taste bristle | subset of prothoracic tarsal segment 5
      (Ling et al., 2014)
      sugar-sensing neuron of taste bristle | subset of prothoracic tarsal segment 4
      (Ling et al., 2014)
      sugar-sensing neuron of taste bristle | subset of mesothoracic tarsal segment 5
      (Ling et al., 2014)
      sugar-sensing neuron of taste bristle | subset of mesothoracic tarsal segment 4
      (Ling et al., 2014)
      sugar-sensing neuron of taste bristle | subset of metathoracic tarsal segment 5
      (Ling et al., 2014)
      sugar-sensing neuron of taste bristle | subset of metathoracic tarsal segment 4
      (Ling et al., 2014)
      gustatory receptor neuron of adult labellum sensillum | subset
      (Weiss et al., 2011)
      sugar-sensing neuron of taste bristle | subset of adult labellum sensillum
      (Weiss et al., 2011)
      L-type sensillum L1 | intense
      (Weiss et al., 2011)
      L-type sensillum L2 | intense
      (Weiss et al., 2011)
      L-type sensillum L4 | intense
      (Weiss et al., 2011)
      L-type sensillum L6 | intense
      (Weiss et al., 2011)
      L-type sensillum L8 | intense
      (Weiss et al., 2011)
      L-type sensillum L9 | intense
      (Weiss et al., 2011)
      L-type sensillum L3
      (Weiss et al., 2011)
      L-type sensillum L5
      (Weiss et al., 2011)
      L-type sensillum L7 | intense
      (Weiss et al., 2011)
      sugar-sensing neuron of taste bristle of intermediate labellar taste bristle I-a
      (Fujii et al., 2015)
      sugar-sensing neuron of taste bristle of intermediate labellar taste bristle I-b
      (Fujii et al., 2015)
      sugar-sensing neuron of taste bristle of large labellar taste bristle
      (Fujii et al., 2015)
      prothoracic leg taste bristle chemosensory neuron of tarsal segment 4
      (Fujii et al., 2015)
      prothoracic leg taste bristle chemosensory neuron of tarsal segment 5
      (Fujii et al., 2015)
      sugar-sensing neuron of taste bristle of prothoracic leg taste bristle chemosensory neuron
      (Fujii et al., 2015)
      gustatory receptor neuron | subset of pseudotracheal taste peg
      (Fujii et al., 2015)
      gustatory receptor neuron | subset of labral sense organ neuron
      (Fujii et al., 2015)
      adult subesophageal zone | restricted
      (Fujii et al., 2015)
      prothoracic leg taste bristle ascending tarsal chemosensory neuron
      (Thoma et al., 2016)
      prothoracic leg taste bristle segmental tarsal chemosensory neuron
      (Thoma et al., 2016)
      adult abdominal multidendritic neuron | subset
      (Park and Kwon, 2011)
      Additional Information
      Statement
      Reference

      Drives expression in a subset of sugar-sensing neurons.

      (FlyBase Curators, 2017)

      ScerGAL4Gr61a.4.9 drives expression in about 12 sugar-sensing chemosensory neurons in the prothoracic leg. A subset of the leg neurons project to the ventral nerve cord then ascend through the cervical connective to the posterior gnathal gangion.

      (Thoma et al., 2016)

      ScerGAL4Gr61a.4.9 drives expression in 1-2 gustatory receptor neurons associated with the taste pegs and 4 gustatory receptor neurons of the adult labral sense organ. All of the labellar neurons and many of the tarsal S cells send projections to the adult subesophageal zone.

      (Fujii et al., 2015)

      ScerGAL4Gr61a.4.9 drives expression in adult abdominal multidendritic neurons with with dorsal processes extending along the left-right axis, as well as in multidendritic neurons with lateral processes extending anteroposteriorly; these major processes have several protruding dendrites. Additionally, expression is driven in multidendritic neurons with ladder-like processes along the dorsal abdominal wall.

      (Park and Kwon, 2011)

      ScerGAL4Gr61a.4.9 is expressed in most of the long sugar-sensitive neuron of the taste sensilla of the labellum.

      (Weiss et al., 2011)

      ScerGAL4Gr61a.4.9 is expressed in the long sugar-sensitive receptor neurons of the gustatory sensilla of the labellum.

      (Weiss et al., 2011)
       
      Marker for
      Reflects expression of
      Gr61a
      (Thoma et al., 2016, Fujii et al., 2015, Ling et al., 2014, Park and Kwon, 2011, Weiss et al., 2011, Weiss et al., 2011)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using Hsap\KCNJ2UAS.EGFP) of Scer\GAL4Gr61a.4.9 cells in adults significantly reduces preference for sucrose, compared to controls. When inhibition is restricted to a smaller set of cells (using Ecol\lexAVP16.Gr5a.cGa and Scer\GAL80IVS.WPRE.8xlexAop) there is still a significant reduction in preference for sucrose, compared to controls.

      (Thoma et al., 2016)

      Ablation of Scer\GAL4Gr61a.4.9-expressing neurons does not affect sensitivity to the gustatory sex pheromone (S,Z,Z)-CH503: as in wild type, courtship defects are seen in these flies in response to (S,Z,Z)-CH503.

      (Shankar et al., 2015)

      Inhibition (using Ork1Δ-C.UAS.EGFP) of Scer\GAL4Gr61a.4.9 cells in adults given a choice between sucrose solution and water does not affect water or sucrose consumption, compared to controls.

      (Sun et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4Gr61a.4.9/Gr64aUAS.cUa is a suppressor | partially of abnormal neurophysiology | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9/Gr64aUAS.cUa is a suppressor | partially of abnormal taste perception | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9/Gr61aUAS.cUa is a suppressor | partially of abnormal neurophysiology | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9/Gr61aUAS.cUa is a suppressor | partially of abnormal taste perception | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9, Gr64bUAS.cUa, Gr64eUAS.cUa is a suppressor | partially of abnormal neurophysiology | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9, Gr64bUAS.cUa, Gr64eUAS.cUa is a suppressor | partially of abnormal taste perception | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9, Gr64aUAS.cUa, Gr64eUAS.cUa is a suppressor | partially of abnormal neurophysiology | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9, Gr64aUAS.cUa, Gr64eUAS.cUa is a suppressor | partially of abnormal taste perception | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr5aUAS.cUa/Scer\GAL4Gr61a.4.9 is a suppressor | partially of abnormal neurophysiology | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr5aUAS.cUa/Scer\GAL4Gr61a.4.9 is a suppressor | partially of abnormal taste perception | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4Gr61a.4.9/Gr64bUAS.cUa is a non-suppressor of abnormal neurophysiology | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9/Gr64bUAS.cUa is a non-suppressor of abnormal taste perception | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9, Gr64bUAS.cUa, Gr64aUAS.cUa is a non-suppressor of abnormal neurophysiology | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9, Gr64bUAS.cUa, Gr64aUAS.cUa is a non-suppressor of abnormal taste perception | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64dUAS.cUa, Scer\GAL4Gr61a.4.9, Gr64aUAS.cUa is a non-suppressor of abnormal neurophysiology | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64dUAS.cUa, Scer\GAL4Gr61a.4.9, Gr64aUAS.cUa is a non-suppressor of abnormal taste perception | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64cUAS.cUa/Scer\GAL4Gr61a.4.9 is a non-suppressor of abnormal neurophysiology | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64cUAS.cUa/Scer\GAL4Gr61a.4.9 is a non-suppressor of abnormal taste perception | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64dUAS.cUa/Scer\GAL4Gr61a.4.9 is a non-suppressor of abnormal neurophysiology | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64dUAS.cUa/Scer\GAL4Gr61a.4.9 is a non-suppressor of abnormal taste perception | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9/Gr64eUAS.cUa is a non-suppressor of abnormal neurophysiology | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9/Gr64eUAS.cUa is a non-suppressor of abnormal taste perception | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64fUAS.cUa/Scer\GAL4Gr61a.4.9 is a non-suppressor of abnormal neurophysiology | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64fUAS.cUa/Scer\GAL4Gr61a.4.9 is a non-suppressor of abnormal taste perception | adult stage phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4Gr61a.4.9/Gr64bUAS.cUa is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9/Gr64bUAS.cUa is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64cUAS.cUa/Scer\GAL4Gr61a.4.9 is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64cUAS.cUa/Scer\GAL4Gr61a.4.9 is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64dUAS.cUa/Scer\GAL4Gr61a.4.9 is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64dUAS.cUa/Scer\GAL4Gr61a.4.9 is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9/Gr64eUAS.cUa is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9/Gr64eUAS.cUa is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64fUAS.cUa/Scer\GAL4Gr61a.4.9 is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64fUAS.cUa/Scer\GAL4Gr61a.4.9 is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9, Gr64bUAS.cUa, Gr64aUAS.cUa is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9, Gr64bUAS.cUa, Gr64aUAS.cUa is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64dUAS.cUa, Scer\GAL4Gr61a.4.9, Gr64aUAS.cUa is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr64dUAS.cUa, Scer\GAL4Gr61a.4.9, Gr64aUAS.cUa is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9/Gr64aUAS.cUa is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9/Gr61aUAS.cUa is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9, Gr64bUAS.cUa, Gr64eUAS.cUa is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Scer\GAL4Gr61a.4.9, Gr64aUAS.cUa, Gr64eUAS.cUa is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)

      Gr5aUAS.cUa/Scer\GAL4Gr61a.4.9 is a non-suppressor of sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype of Df(3L)ΔGr64, Gr5aLEXA, Gr61a1

      (Yavuz et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4Gr61a.4.9
      Name Synonyms
      Secondary FlyBase IDs
        References (21)