FlyBase Allele Report: Hsap\PPP2R2B[UAS.cYa]

General Information

Symbol

Hsap\PPP2R2B^UAS.cYa

Species

H. sapiens

Name

FlyBase ID

FBal0256738

Feature type

allele

Associated gene

Hsap\PPP2R2B

Associated Insertion(s)

Carried in Construct

P{UAS-BΒ2.Y}

Also Known As

UAS-BΒ2

Key Links

Transgenic product class

wild_type

(Yeh et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Yeh et al., 2010)

Mutagen

in vitro construct

(Yeh et al., 2010)

Progenitor genotype

Carried in construct

P{UAS-BΒ2.Y}

Cytology

Description

UASt regulatory sequences drive expression of Hsap\PPP2R2B coding sequences.

(Yeh et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\PPP2R2B

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autosomal dominant cerebellar ataxia

CEA

(Wang et al., 2011)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | embryonic stage, with Scer\GAL4^Act5C.PU

(Wang et al., 2011)

increased cell death | embryonic stage, with Scer\GAL4^elav.PU

(Wang et al., 2011)

short lived | heat sensitive, with Scer\GAL4^elav.PU

(Wang et al., 2011)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Hsap\PPP2R5B^Scer\UAS.cYa under the control of either Scer\GAL4^elav.PU or Scer\GAL4^Act5C.PU results in a large number of apoptotic cells in embryos.

Flies expressing Hsap\PPP2R5B^Scer\UAS.cYa under the control of Scer\GAL4^elav.PU at 29[o]C show a significant reduction in lifespan compared to controls.

Flies expressing Hsap\PPP2R5B^Scer\UAS.cYa under the control of Scer\GAL4^elav.PU at 29[o]C and treated with 20mM paraquat show reduced climbing ability compared to control flies.

(Wang et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\PPP2R2B^UAS.cYa, Scer\GAL4^Eq is a suppressor of macrochaeta phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^Eq

(Yeh et al., 2010)

Hsap\PPP2R2B^UAS.cYa, Scer\GAL4^Eq is a suppressor of sensory organ cell phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^Eq

(Yeh et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\BΒ2^Scer\UAS.cYa mitigates the Hsap\MAPT^Scer\UAS.cWa-induced bristle loss phenotype (with both under the control of Scer\GAL4^Eq1). Bristle and sensory cell numbers increase concurrently when Hsap\BΒ2^Scer\UAS.cYa is co-expressed with Hsap\MAPT^Scer\UAS.cWa.

(Yeh et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\BΒ2^Scer\UAS.cYa

Hsap\PPP2R2B^Scer\UAS.cYa

Hsap\PPP2R2B^UAS.cYa

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close