FlyBase Allele Report: Dmel\TrpA1[-FRT.UAS.cvPa]

General Information

Symbol

Dmel\TrpA1^{-FRT.UAS.cvPa}

Species

D. melanogaster

Name

FlyBase ID

FBal0256968

Feature type

allele

Associated gene

Dmel\TrpA1

Associated Insertion(s)

Carried in Construct

P{UAS(-FRT)TrpA1.P}

Key Links

Transgenic product class

wild_type

(von Philipsborn et al., 2011)

Mutagen

FLPase

Nature of the Allele

Transgenic product class

wild_type

(von Philipsborn et al., 2011)

Mutagen

FLPase

(von Philipsborn et al., 2011)

Progenitor genotype

TrpA1^FRT.stop.UAS

(von Philipsborn et al., 2011)

Carried in construct

P{UAS(-FRT)TrpA1.P}

Cytology

Description

The FRT cassette containing transcriptional stop sequences has been excised, allowing the UAS regulatory sequences to drive expression of the TrpA1 coding region.

(von Philipsborn et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

TrpA1

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | heat sensitive, with Scer\FLP1^fru, Scer\GAL4^5-HT1B.PY

(Yuan et al., 2014)

abnormal behavior | heat sensitive, with Scer\FLP1^fru, Scer\GAL4^Gad1.PS

(Yuan et al., 2014)

abnormal behavior | heat sensitive, with Scer\FLP1^fru, Scer\GAL4^Rdl.PS

(Yuan et al., 2014)

abnormal courtship behavior | male | somatic clone | heat sensitive, with Scer\FLP1^fru, Scer\GAL4^ppk23.2.336

(Toda et al., 2012)

abnormal song | heat sensitive, with Scer\GAL4^fru.P1.D

(von Philipsborn et al., 2011)

abnormal song | heat sensitive, with Scer\GAL4^NP2631

(von Philipsborn et al., 2011)

abnormal song | heat sensitive, with Scer\GAL4^nSyb.PS

(von Philipsborn et al., 2011)

abnormal song | heat sensitive, with Scer\GAL4^VT005534

(von Philipsborn et al., 2011)

abnormal song | heat sensitive, with Scer\GAL4^VT017258

(von Philipsborn et al., 2011)

abnormal song | heat sensitive, with Scer\GAL4^VT019579

(von Philipsborn et al., 2011)

abnormal song | heat sensitive, with Scer\GAL4^VT040556

(von Philipsborn et al., 2011)

abnormal song | heat sensitive, with Scer\GAL4^VT041688

(von Philipsborn et al., 2011)

abnormal song | heat sensitive, with Scer\GAL4^VT043702

(von Philipsborn et al., 2011)

abnormal song | heat sensitive, with Scer\GAL4^VT046099

(von Philipsborn et al., 2011)

abnormal song | heat sensitive, with Scer\GAL4^VT057239

(von Philipsborn et al., 2011)

Phenotype Manifest In

Detailed Description

Statement

Reference

Activation of neurons expressing both 5-HT1B and fru (through heat-induced expression of TrpA1^{-FRT.Scer\UAS.cvPa} under the control of Scer\GAL4^5-HT1B.PY and in which the Scer\FRT stop cassette has been removed by Scer\FLP1^fru) inhibits baseline female contact-induced male-male aggression. Suppressing expression in the mushroom body neurons using Scer\GAL80^Mef2.mb247 does not block this inhibition. Suppression of GABA neuron expression using Scer\GAL80^Gad1 blocks the inhibition.

Activation of GABA+ neurons expressing fru (through heat-induced expression of TrpA1^{-FRT.Scer\UAS.cvPa} under the control of Scer\GAL4^Gad1.PS and in which the Scer\FRT stop cassette has been removed by Scer\FLP1^fru) inhibits female contact-induced male-male aggression.

Activation of neurons expressing both Rdl and fru (through heat-induced expression of TrpA1^{-FRT.Scer\UAS.cvPa} under the control of Scer\GAL4^Rdl.PS and in which the Scer\FRT stop cassette has been removed by Scer\FLP1^fru) inhibits baseline female contact-induced male-male aggression.

(Yuan et al., 2014)

Males in which expression of TrpA1^{Scer\UAS.cvPa} under the control of Scer\GAL4^ppk23.2.336 is activated in the fru[+]expressing subset of ppk23[+] neurons (using Scer\FLP1^fru to generate TrpA1^{Scer\UAS.cvPa} from TrpA1^{Scer\FRT.stop.Scer\UAS} in these cells) by increased temperature show courtship towards wild-type males.

(Toda et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

TrpA1^{-FRT.Scer\UAS.cvPa}

TrpA1^{-FRT.UAS.cvPa}

TrpA1^{Scer\UAS.cvPa}

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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