FlyBase Allele Report: Scer\FLP1[fru]

General Information

Symbol

Scer\FLP1^fru

Species

S. cerevisiae

Name

FlyBase ID

FBal0248672

Feature type

allele

Associated gene

Scer\FLP1

Associated Insertion(s)

TI{FLP}fru^FLP

Carried in Construct

Also Known As

fru^FLP, fruFLP, fru-FLP

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

recombination

(Yu et al., 2010)

gene targeting by homologous recombination

(Yu et al., 2010)

Progenitor genotype

Associated Insertion(s)

TI{FLP}fru^FLP

Cytology

Description

The entire fru S exon (including its sex-specific splice sites) has been replaced by the FLP recombinase coding region. This results in FLP being expressed from the fru P1 promoter, and because the sex-specific splice sites have been removed, expression is uncoupled from the sex determination pathway.

(Yu et al., 2010)

Allele components

Component

Use(s)

Inserted element

TI{FLP}

promoter trap

Encoded product / tool

FLP

recombinase

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^5-HT1B.PY

(Yuan et al., 2014)

abnormal behavior, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^ppk29.3.612

(Yuan et al., 2014)

abnormal behavior, with Hsap\KCNJ2^UAS.GFP, Scer\GAL4^5-HT1B.PY

(Yuan et al., 2014)

abnormal behavior | adult stage | heat sensitive, with Scer\GAL4^GMR15A01, TrpA1^{FRT.stop.UAS.Tag:MYC}

(Hoopfer et al., 2015)

abnormal behavior | adult stage | heat sensitive, with Scer\GAL4^GMR71G01, TrpA1^{FRT.stop.UAS.Tag:MYC}

(Hoopfer et al., 2015)

abnormal behavior | heat sensitive, with Scer\GAL4^5-HT1B.PY, TrpA1^{-FRT.UAS.cvPa}

(Yuan et al., 2014)

abnormal behavior | heat sensitive, with Scer\GAL4^Gad1.PS, TrpA1^{-FRT.UAS.cvPa}

(Yuan et al., 2014)

abnormal behavior | heat sensitive, with Scer\GAL4^Rdl.PS, TrpA1^{-FRT.UAS.cvPa}

(Yuan et al., 2014)

abnormal copulation, with Hsap\KCNJ2^{FRT.Stop.UAS.EGFP}, Scer\GAL4^VGlut-OK371, Scer\GAL80^{tsh-md621-GAL80}

(Takayanagi-Kiya and Kiya, 2019)

abnormal courtship behavior, with Cnoc\ChR1::Csub\ChR^{CsChrimson.20xUAS.FRT.Venus}, Scer\GAL4^{Hr38-02306-G4}

(Takayanagi-Kiya and Kiya, 2019)

abnormal courtship behavior, with Hsap\KCNJ2^{FRT.Stop.UAS.EGFP}, Scer\GAL4^VGlut-OK371, Scer\GAL80^{tsh-md621-GAL80}

(Takayanagi-Kiya and Kiya, 2019)

abnormal courtship behavior, with NPF^KK111846, Scer\GAL4^NPF.1, Scer\GAL80^αTub84B.PG

(Liu et al., 2019)

abnormal courtship behavior | conditional, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^4-57

(Tran et al., 2014)

abnormal courtship behavior | heat sensitive, with Scer\GAL4^NPF.1, shi^{ts.FRT.stop.UAS}

(Liu et al., 2019)

abnormal courtship behavior | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^3-8

(Keleman et al., 2012)

abnormal courtship behavior | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^8-194

(Keleman et al., 2012)

abnormal courtship behavior | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^10-16

(Keleman et al., 2012)

abnormal courtship behavior | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4¹⁴⁷¹

(Keleman et al., 2012)

abnormal courtship behavior | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^NP0368

(Keleman et al., 2012)

abnormal courtship behavior | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^NP3591

(Keleman et al., 2012)

abnormal courtship behavior | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^Or67d-GAL4-1

(Keleman et al., 2012)

abnormal courtship behavior | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^ple.PF

(Keleman et al., 2012)

abnormal courtship behavior | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^Tab2-201Y

(Keleman et al., 2012)

abnormal courtship behavior | male | heat sensitive, with Scer\GAL4^ple.PF, shi^ts.UAS

(Keleman et al., 2012)

abnormal courtship behavior | male | somatic clone | heat sensitive, with Scer\GAL4^ppk23.2.336, TrpA1^{-FRT.UAS.cvPa}

(Toda et al., 2012)

abnormal learning | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^3-8

(Keleman et al., 2012)

abnormal learning | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^8-194

(Keleman et al., 2012)

abnormal learning | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^10-16

(Keleman et al., 2012)

abnormal learning | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4¹⁴⁷¹

(Keleman et al., 2012)

abnormal learning | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^NP0368

(Keleman et al., 2012)

abnormal learning | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^NP3591

(Keleman et al., 2012)

abnormal learning | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^Or67d-GAL4-1

(Keleman et al., 2012)

abnormal learning | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^ple.PF

(Keleman et al., 2012)

abnormal learning | male | heat sensitive, with Ctet\tetX^{TNT-LC.UAS.cSa}, Scer\GAL4^Tab2-201Y

(Keleman et al., 2012)

abnormal mating behavior, with Cnoc\ChR1::Csub\ChR^{CsChrimson.20xUAS.FRT.Venus}, Scer\GAL4^{Hr38-02306-G4}

(Takayanagi-Kiya and Kiya, 2019)

abnormal memory | male | heat sensitive, with Scer\GAL4^ple.PF, shi^ts.UAS

(Keleman et al., 2012)

abnormal song | conditional, with Crei\ChR1::Vcar\ChR1::Vcar\ChR2^{ReaChR.lexAop.FRT.mCherry.Citrine}, Ecol\lexA^VT040556.PU

(O'Sullivan et al., 2018)

abnormal song | conditional, with Crei\ChR1::Vcar\ChR1::Vcar\ChR2^{ReaChR.UAS.FRT.mCherry.Citrine}, Scer\GAL4^GMR22H05, Scer\GAL4^NP2631

(O'Sullivan et al., 2018)

abnormal song | somatic clone, with Camta^GLV21048, Scer\GAL4^p52a

(Sato et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of TrpA1^{Scer\FRT.stop.Scer\UAS} under the control of Scer\GAL4^Dh44-R1.PL and in combination with Scer\FLP1^fru in females does not result in any change in latency to sperm ejection after copulation at either 23[o]C or 30[o]C.

(Lee et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Crei\ChR1::Vcar\ChR1::Vcar\ChR2^{ReaChR.lexAop.FRT.mCherry.Citrine}, Ecol\lexA^VT040556.PU, Scer\FLP1^fru has abnormal song | conditional phenotype, suppressible | conditional by Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}/Scer\GAL4^Tdc2.PC

(O'Sullivan et al., 2018)

Enhancer of

Statement

Reference

TrpA1^{FRT.stop.UAS.Tag:MYC}, Scer\GAL4^NP2631, Scer\FLP1^fru is an enhancer of abnormal courtship behavior | heat sensitive phenotype of Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.13XLexAop2.Venus}, Ecol\lexA^VT029314.PU

(Ribeiro et al., 2018)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

66870

w^*; TI{FLP}fru^FLP/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Scer\FLP1^fru

fru^FLP

(Lee et al., 2023, Brovero et al., 2021, Nojima et al., 2021, Wohl et al., 2020, Liu et al., 2019, O'Sullivan et al., 2018, Ribeiro et al., 2018, Yilmazer et al., 2016, Hoopfer et al., 2015, Krüttner et al., 2015, Lee et al., 2015, Neville et al., 2014, Tran et al., 2014, Vaughan et al., 2014, von Philipsborn et al., 2014, Yuan et al., 2014, Devineni et al., 2013, Toda et al., 2012)

fruFLP

(Tran et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (40)

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