The FLP entry in FlyBase represents a recombinase which is derived from the naturally occurring FLP recombinase encoded by the Saccharomyces cerevisiae 2μ plasmid, but where the precise variant is unknown/unspecified. FLP mediates recombination between a compatible pair of specific target sites such as FRT. The recombination event results in genetic modification, the nature of which is influenced by the relative orientation (direct or inverted), location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombinase-mediated cassette exchange (RMCE) (reviewed in FBrf0231034).