FlyBase Allele Report: Dmel\HDAC1[HMS00607]

General Information

Symbol

Dmel\HDAC1^HMS00607

Species

D. melanogaster

Name

FlyBase ID

FBal0257292

Feature type

allele

Associated gene

Dmel\HDAC1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00607}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00607}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00607

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response | adult stage, with Scer\GAL4^tin.CΔ4

(Kopp et al., 2015)

abnormal taste perception, with Scer\GAL4^{fuss-MI13731-GAL4}

(Rass et al., 2019)

increased cell death, with Scer\GAL4^bbg-C96

(Ellis et al., 2015)

visible, with Scer\GAL4^bbg-C96

(Ellis et al., 2015)

Phenotype Manifest In

chromosome | adult stage | female, with Scer\GAL4^{VP16.mat.αTub67C}

(Nikalayevich and Ohkura, 2015)

oocyte, with Scer\GAL4^{VP16.mat.αTub67C}

(Nikalayevich and Ohkura, 2015)

wing, with Scer\GAL4^bbg-C96

(Ellis et al., 2015)

wing disc, with Scer\GAL4^bbg-C96

(Ellis et al., 2015)

Detailed Description

Statement

Reference

Bitter sensing is impaired in adults expressing HDAC1^HMS00607 under the control of Scer\GAL4^{fuss-MI13731-GAL4}.

(Rass et al., 2019)

Expression of HDAC1^HMS00607 under the control of Scer\GAL4^bbg-C96 results in disorganization of wing structure, wing curling and a subset of wings exhibit nicking, and increased cell death is observed in the wing disc, in a portion of the dorsal-ventral wing margin.

(Ellis et al., 2015)

Expression of HDAC1^HMS00607 under the control of Scer\GAL4^tin.CΔ4 leads to increased survival to paraquat-induced oxidative stress, as compared to controls.

(Kopp et al., 2015)

Expression of HDAC1^HMS00607 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} results in significantly increased frequency of undercondensed chromosomes in mature oocytes compared to controls.

(Nikalayevich and Ohkura, 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

HDAC1^HMS00607, Scer\GAL4^bbg-C96 is a suppressor of visible phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Ellis et al., 2015)

HDAC1^HMS00607, Scer\GAL4^bbg-C96 is a suppressor of increased cell death phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Ellis et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

HDAC1^HMS00607, Scer\GAL4^bbg-C96 is a suppressor of wing phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Ellis et al., 2015)

HDAC1^HMS00607, Scer\GAL4^bbg-C96 is a suppressor of wing disc phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Ellis et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of HDAC1^HMS00607 suppresses the wing nicking phenotype, and suppresses the wing disc increased cell death along the dorsal-ventral wing margin of flies expressing dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96.

(Ellis et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

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