FlyBase Allele Report: Dmel\cnc[HMS00650]

General Information

Symbol

Dmel\cnc^HMS00650

Species

D. melanogaster

Name

FlyBase ID

FBal0257334

Feature type

allele

Associated gene

Dmel\cnc

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00650}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00650}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00650

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates intestinal cancer

modeled by N^RNAi.P.UAS

(Chen et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4²²¹

(Iyer et al., 2013)

abnormal neuroanatomy, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

Phenotype Manifest In

abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

abdominal ventral multidendritic neuron v'dap, with Scer\GAL4²²¹

(Iyer et al., 2013)

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

larval dorsal multidendritic neuron ddaE, with Scer\GAL4²²¹

(Iyer et al., 2013)

testis, with Scer\GAL4^bam.PU

(Chen et al., 2020)

Detailed Description

Statement

Reference

Expression of cnc^HMS00650 under the control of Scer\GAL4^bam.PU leads to accumulation of undifferentiated cells at the apex of the testis when compared to controls.

(Chen et al., 2020)

Expression of cnc^HMS00650 in C-I neurons under the control of Scer\GAL4²²¹ results in ddaE neurons that have an increased number of dendritic branches compared to controls. The total dendritic length is reduced in ddaD and vpda neurons.

Expression of cnc^HMS00650 in C-IV neurons under the control of Scer\GAL4^ppk.1.9 results in a reduction in total dendritic length in ddaC and v'ada neurons. The total number of dendritic branches is also reduced in ddaC neurons.

(Iyer et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^bam.PU, cnc^HMS00650 has testis phenotype, enhanceable by bam^Δ86

(Chen et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

32863

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00650}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CncC^RNAi

(Chen et al., 2021)

cnc^HMS00650

cnc[i3, HMS00650]

(Nagy et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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