FB2024_02 , released April 23, 2024
Allele: Dmel\ktoHMS01062
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General Information
Symbol
Dmel\ktoHMS01062
Species
D. melanogaster
Name
FlyBase ID
FBal0257726
Feature type
allele
Associated gene
Dmel\kto
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS01062}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct - RNAi
(Ni et al., 2010.12.1)
in vitro construct - regulatory fusion
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMS01062}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS01062
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  obesity
      CEA
      (Lee et al., 2014)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTTQ128.UAS
      (Martin et al., 2021)
      exacerbates  cancer
      modeled by RbfHMS03004
      (Parkhitko et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      All flies expressing ktoHMS01062 under the control of Scer\GAL4ey.200.Exel in combination with Scer\GAL4GMR.PFa have greatly reduced eyes.

      Adults expressing ktoHMS01062 under the control of Scer\GAL4Mef2.PR have a normal life span under standard diet, but live longer than controls when starved.

      (Lee et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      ktoHMS01062, Scer\GAL4repo.Switch.2301 is a suppressor | partially of short lived | RU486 conditional phenotype of Hsap\HTTQ128.UAS, Scer\GAL4repo.Switch.2301

      (Martin et al., 2021)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ktoHMS01062
      Name Synonyms
      Secondary FlyBase IDs
        References (7)