FB2024_03 , released June 25, 2024
Allele: Dmel\Sk2UAS.cYa
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General Information
Symbol
Dmel\Sk2UAS.cYa
Species
D. melanogaster
Name
FlyBase ID
FBal0258133
Feature type
allele
Associated gene
Dmel\Sk2
Associated Insertion(s)
Carried in Construct
P{UAS-Sk2.Y}
Key Links
Transgenic product class
cDNA
(Yonamine et al., 2011)
wild_type
(Yonamine et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Yonamine et al., 2011)
wild_type
(Yonamine et al., 2011)
Mutagen
in vitro construct
(Yonamine et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Sk2.Y}
Cytology
Description

UAS regulatory sequences drive expression of Sk2 cDNA sequences.

(Yonamine et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sk2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of Sk2Scer\UAS.cYa in the developing eye under the control of Scer\GAL4GMR.PF leads to extensive photoreceptor degeneration: very few intact ommatidia are seen, rhabdomeres are lost, and cells are vacuolated.

      Sk2Scer\UAS.cYa, Scer\GAL4GMR.PF, Scer\GAL80ts.αTub84B photoreceptors that have been raised at a permissive temperature, where Sk2Scer\UAS.cYa expression is inhibited for the first 2 days post eclosion exhibit photoreceptor degeneration after being moved to a non-permissive temperature (where Sk2Scer\UAS.cYa is expressed).

      (Yonamine et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A car1 mutant background suppresses the retinal degeneration seen upon expression of Sk2Scer\UAS.cYa under the control of Scer\GAL4GMR.PF in the developing eye through enhanced lysosomal degradation.

      CalxB mutant background partially suppresses the degeneration of photoreceptors found when Sk2Scer\UAS.cYa is overexpressed in the developing eye under the control of Scer\GAL4GMR.PF.

      (Yonamine et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sk2Scer\UAS.cYa
      Sk2UAS.cYa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)