FB2024_03 , released June 25, 2024
Allele: Dmel\tyfΔG14151
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General Information
Symbol
Dmel\tyfΔG14151
Species
D. melanogaster
Name
FlyBase ID
FBal0258576
Feature type
allele
Associated gene
Dmel\tyf
Associated Insertion(s)
Carried in Construct
Also Known As
tyfΔ
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Lim et al., 2011)
Progenitor genotype
P{EP}G14151
(Lim et al., 2011)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a deletion of approximately 2.5kb which removes sequences encoding tyf amino acid residues 79-449 and results in a frameshift and a premature stop codon.

(Lim et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:4,118,652..4,121,119 [+]
Comment:

Approximate boundaries of ~2.5 kb deletion that removes residues 79-449 of tyf.

(Lim et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies show defects in locomotor activity rhythms; under 12 hour light/12 hour dark conditions, the morning anticipation of lights-on is reduced compared to controls, and the rhythm is less robust, resulting in weak (43% of flies are rhythmic) but long periods (25.6 +/- 0.8 hours) under constant darkness conditions.

      (Lim et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      tyfΔG14151 has abnormal locomotor rhythm phenotype, suppressible by perUAS.cBa/Scer\GAL4P2.4.Pdf

      (Lim et al., 2011)
      NOT suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The weakened rhythmicity seen in tyfΔG14151 flies under constant darkness conditions is suppressed by expression of perScer\UAS.cBa under the control of Scer\GAL4P2.4.Pdf but is not suppressed by expression of either timScer\UAS.cYa or ClkScer\UAS.cZa under the control of Scer\GAL4P2.4.Pdf.

      (Lim et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      tyfΔG14151 is rescued by tyfUAS.Tag:V5/Scer\GAL4P2.4.Pdf

      (Lim and Allada, 2013)

      tyfΔG14151 is rescued by tyfUAS.Tag:FLAG/Scer\GAL4P2.4.Pdf

      (Lim and Allada, 2013)

      tyfΔG14151 is rescued by tyfUAS.Tag:V5/Scer\GAL4P2.4.Pdf

      (Lim et al., 2011)
      Not rescued by

      tyfΔG14151 is not rescued by tyfΔC5.UAS.Tag:V5/Scer\GAL4P2.4.Pdf

      (Lim and Allada, 2013)

      tyfΔG14151 is not rescued by tyfΔC5.UAS.Tag:FLAG/Scer\GAL4P2.4.Pdf

      (Lim and Allada, 2013)
      Comments

      Expression of tyfScer\UAS.T:SV5\V5 under the control of Scer\GAL4P2.4.Pdf rescues the locomotor rhythm defects seen in tyfΔG14151 mutant flies.

      Expression of tyfScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4P2.4.Pdf rescues the locomotor rhythm defects seen in tyfΔG14151 mutant flies.

      Expression of tyfΔC5.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4P2.4.Pdf fails to rescue the locomotor rhythm defects seen in tyfΔG14151 mutant flies.

      Expression of tyfΔC5.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4P2.4.Pdf fails to rescue the locomotor rhythm defects seen in tyfΔG14151 mutant flies.

      (Lim and Allada, 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tyfΔ
      (Lim and Allada, 2013, Lim et al., 2011)
      tyfΔG14151
      (Lim et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)