FB2024_03 , released June 25, 2024
Allele: Dmel\rprLZ.UAS
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General Information
Symbol
Dmel\rprLZ.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0260665
Feature type
allele
Associated gene
Dmel\rpr
Associated Insertion(s)
Carried in Construct
P{UAS-rpr.LZ}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Sandu et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-rpr.LZ}
Cytology
Description

UAS regulatory sequences drive expression of rpr sequences fused with a parallel leucine zipper (LZ) from the Saccharomyces cerevisiae GCN4 transcription factor. This is designed to result in an enforced parallel-rpr protein dimer.

(Sandu et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
rpr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of rprScer\UAS.T:Scer\GCN4 in the developing eye under the control of Scer\GAL4GMR.PF trigers massive cell death, as evidenced by a partially ablated adult eye structure.

      (Sandu et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Scer\GAL4GMR.PF, rprLZ.UAS has eye phenotype, suppressible by Diap16-3s/th[+]

      (Sandu et al., 2010)

      Scer\GAL4GMR.PF, rprLZ.UAS has eye phenotype, suppressible by Diap123-4s/th[+]

      (Sandu et al., 2010)

      Scer\GAL4GMR.PF, rprLZ.UAS has eye phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4GMR.PF

      (Sandu et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A th6-3s or th23-4s heterozygous background significantly suppresses apoptosis induced by expression of rprScer\UAS.T:Scer\GCN4 under the control of Scer\GAL4GMR.PF.

      (Sandu et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of BacA\p35Scer\UAS.cHa rescues eye morphology in flies also expressing rprScer\UAS.T:Scer\GCN4 under the control of Scer\GAL4GMR.PF.

      (Sandu et al., 2010)
      Complementation and Rescue Data
      Rescued by

      rprLZ.UAS is rescued by rprUTR.UAS.Tag:HA/Scer\GAL4GMR.PF

      (Sandu et al., 2010)
      Comments

      Co-expression of rprUTR.Scer\UAS.T:Ivir\HA1 rescues eye morphology in flies also expressing rprScer\UAS.T:Scer\GCN4 under the control of Scer\GAL4GMR.PF.

      (Sandu et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      rprLZ.UAS
      rprScer\UAS.T:Scer\GCN4
      Name Synonyms
      Secondary FlyBase IDs
        References (1)