FB2024_03 , released June 25, 2024
Allele: Dmel\et18A
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General Information
Symbol
Dmel\et18A
Species
D. melanogaster
Name
FlyBase ID
FBal0264423
Feature type
allele
Associated gene
Dmel\et
Associated Insertion(s)
TI{TI}et18A
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Makki et al., 2010)
Mutagen
gene targeting by homologous recombination
(Makki et al., 2010)
Progenitor genotype
Associated Insertion(s)
TI{TI}et18A
Cytology
Description

The et gene has been deleted and replaced by a w+mW.hs marker.

(Makki et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In sharp contrast to wild-type, virtually no circulating lamellocytes are found in the hemolymph of parasitised et18A mutant larvae, either 48 or 72 hours after wasp egg-laying. Several days later, adult wasps hatch from parasitised et18A mutant pupae.

      Homozygous et18A mutants do not exhibit defects in the adult eye or larval stages.

      (Makki et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      et18A has lamellocyte phenotype, suppressible by hopRNAi.UAS.cMa/Scer\GAL4srp.D.cCa

      (Makki et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Reducing the level of hop through expression of hopdsRNA.Scer\UAS.cMa under the control of Scer\GAL4srp.D.cCa results in a lowering of JAK/STAT signalling and concurrently rescues the et18A mutant phenotype, restoring the ability of et18A mutant lymph glands to produce lamellocytes following wasp parasitism.

      (Makki et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      et18A is rescued by etUAS.cMa/Scer\GAL4srp.D.cCa

      (Makki et al., 2010)
      Comments

      Expression of etScer\UAS.cMa under the control of Scer\GAL4srp.D.cCa restores the ability of et18A mutant larvae to produce lamellocytes following wasp parasitisation.

      (Makki et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      et18A
      lat18A
      (Makki et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)