FB2024_03 , released June 25, 2024
Allele: Hsap\TOR1AUAS.cWa
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General Information
Symbol
Hsap\TOR1AUAS.cWa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct of Wakabayashi-Ito
FlyBase ID
FBal0264565
Feature type
allele
Associated gene
Hsap\TOR1A
Associated Insertion(s)
Carried in Construct
P{UAS-htorsinA.W}
Also Known As
UAS-htorsinA
Key Links
Transgenic product class
cDNA
(Wakabayashi-Ito et al., 2011)
wild_type
(Wakabayashi-Ito et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Wakabayashi-Ito et al., 2011)
wild_type
(Wakabayashi-Ito et al., 2011)
Mutagen
in vitro construct
(Wakabayashi-Ito et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-htorsinA.W}
Cytology
Description

UAS drives expression of a 1.0 kb Hsap\TOR1A cDNA.

(Wakabayashi-Ito et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\TOR1A
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  dystonia
      modeled by TorsinKO13
      (Wakabayashi-Ito et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\TOR1AScer\UAS.cWa under the control of Scer\GAL4elav.PU has no significant effect on larval locomotion (peristaltic rate) in third instar larvae.

      (Wakabayashi-Ito et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The deficit in larval (decreased peristaltic rate) as well as adult locomotion characteristic for TorsinKO13/Y hemizygotes can be rescued by expression of Hsap\TOR1AScer\UAS.cWa, but not by combined expression of Hsap\TOR1AScer\UAS.cWa and Hsap\TOR1AΔE.Scer\UAS.cWa) under the control of Scer\GAL4elav.PU in the mutant background.

      (Wakabayashi-Ito et al., 2015)

      Expression of Hsap\TOR1AScer\UAS.cWa using Scer\GAL4Act5C.PU or Scer\GAL4tub.PU rescues the pigmentation, bristle and mobility defects of TorsinKO13/Y animals at very low frequency.

      Expression of Hsap\TOR1AScer\UAS.cWa using Scer\GAL4elav.PU results in a very significant rescue of the TorsinKO13/Y larval mobility defect.

      (Wakabayashi-Ito et al., 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\TOR1AScer\UAS.cWa
      Hsap\TOR1AUAS.cWa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct of Wakabayashi-Ito
      Secondary FlyBase IDs
        References (2)