FB2024_03 , released June 25, 2024
Allele: Dmel\Caf1-55med
Open Close
General Information
Symbol
Dmel\Caf1-55med
Species
D. melanogaster
Name
FlyBase ID
FBal0265621
Feature type
allele
Associated gene
Dmel\Caf1-55
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: W304term.

    (Anderson et al., 2011)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:15,226,967..15,226,967 [+]
    Nucleotide change:

    G15226967A

    Amino acid change:

    W305term | Caf1-55-PA; W304term | Caf1-55-PB

    Reported amino acid change:

    W304term

    Comment:

    G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Anderson et al., 2011)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous larvae appear grossly normal but mature slowly and die as first or second instars.

        Approximately 20% of flies containing clones induced using the ey-FLP; FRT cell lethal system have extra or missing appendages on the head, including the ocelli, antennae and maxillary palps.

        Caf1short/Caf1med flies expressing Caf1Scer\UAS.cAa under the control of Scer\GAL4Ubi and raised at 18[o]C during the third larval instar stage have disorganised kidney-shaped eyes with abnormalities in the arrangement of rhabdomeres (including loss of small central rhabdomeres) and show homeotic transformation of the arista to leg-like structures that occasionally end in claws. These defects are not seen if the animals are raised at 25[o]C during the third larval instar stage.

        (Anderson et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        Caf1-55med/Caf1[+] is a suppressor of visible phenotype of Scer\GAL4lz-gal4, sensUAS.cNa

        (Anderson et al., 2011)
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        Caf1-55med/Caf1[+] is a suppressor of eye phenotype of Scer\GAL4lz-gal4, sensUAS.cNa

        (Anderson et al., 2011)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The mutant eye phenotype caused by expression of sensScer\UAS.cNa under the control of Scer\GAL4lz-gal4 is dominantly suppressed by Caf1med.

        (Anderson et al., 2011)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Caf1-55med/Caf1-55short is rescued by Caf1-55+t12

        (Anderson et al., 2011)
        Partially rescued by

        Caf1-55med/Caf1-55short is partially rescued by Scer\GAL4Ubi.PU/Caf1-55UAS.cAa

        (Anderson et al., 2011)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Caf1-55med
        Caf1med
        (Anderson et al., 2011)
        Caf1p55med
        (Collins and Moon, 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)