FB2024_03 , released June 25, 2024
Allele: Dmel\TBPHUAS.cLa
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General Information
Symbol
Dmel\TBPHUAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Lin
FlyBase ID
FBal0265708
Feature type
allele
Associated gene
Dmel\TBPH
Associated Insertion(s)
Carried in Construct
P{UAS-TBPH.L}
Key Links
Transgenic product class
cDNA
(Lin et al., 2011)
wild_type
(Lin et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Lin et al., 2011)
wild_type
(Lin et al., 2011)
Mutagen
in vitro construct
(Lin et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-TBPH.L}
Cytology
Description

UAS regulatory sequences drive expression of the TBPH GH09868 cDNA.

(Lin et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
TBPH
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  amyotrophic lateral sclerosis type 10
      is exacerbated by S6kSTDETE.UAS
      (Cheng et al., 2015)
      is exacerbated by Scer\GAL80ts.αTub84B
      (Cheng et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of TBPHScer\UAS.cLa under the control of Scer\GAL4ey-OK107 results in shorter mushroom body lobes than normal. The flies show a severe reduction in performance in an odour avoidance learning assay compared to controls.

      Expression of TBPHScer\UAS.cLa under the control of Scer\GAL4D42 can result in pupal lethality or a shortening of the adult lifespan, depending on the level of expression of TBPHScer\UAS.cLa. Animals that survive to adulthood show an age-dependent decrease in locomotion compared to controls.

      Expression of TBPHScer\UAS.cLa under the control of Scer\GAL4D42 can result in defects in larval locomotion, depending on the level of expression of TBPHScer\UAS.cLa.

      Expression of TBPHScer\UAS.cLa under the control of Scer\GAL4D42 can result in a decrease in the number of synaptic boutons normalised to the muscle area at the neuromuscular junction of third instar larvae, depending on the level of expression of TBPHScer\UAS.cLa.

      (Lin et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      TBPHUAS.cLa/Scer\GAL4Toll-6-D42 rescues TBPHex26

      (Lin et al., 2011)
      Comments

      The locomotion defects and the increased number of synaptic boutons at the neuromuscular junction which are seen in TBPHex26 larvae are fully and partially rescued respectively by expression of TBPHScer\UAS.cLa under the control of Scer\GAL4D42.

      (Lin et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TBPHScer\UAS.cLa
      TBPHUAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Lin
      Secondary FlyBase IDs
        References (2)